The Function of SLCO1B3
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.
Protein names
Recommended name:
Solute carrier organic anion transporter family member 1B3Short name:
LST-2Alternative name(s):
Liver-specific organic anion transporter 2Organic anion transporter 8
Organic anion-transporting polypeptide 8
OATP-8
Solute carrier family 21 member 8
- RS11045585 (SLCO1B3) ??
- RS2117032 (SLCO1B3) ??
- RS2417940 (SLCO1B3) ??
- RS4149117 (SLCO1B3) ??
- RS7311358 (SLCO1B3) ??
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Top Gene-Substance Interactions
SLCO1B3 Interacts with These Diseases
Disease | Score |
Substances That Increase SLCO1B3
Substances | Interaction | Organism | Category |
Substances That Decrease SLCO1B3
Substances | Interaction | Organism | Category |
Advanced Summary
Rotor syndrome Mutations in the SLCO1B3 gene are involved in Rotor syndrome. This condition is characterized by elevated levels of bilirubin in the blood that can cause yellowing of the skin and whites of the eyes (jaundice). For this condition to occur, individuals must have mutations in the SLCO1B3 gene and a related gene called SLCO1B1. This related gene provides instructions for making a protein called OATP1B1, which has a similar transport function to OATP1B3. In some cases, the condition is caused by a deletion of genetic material that removes parts of both the SLCO1B3 and SLCO1B1 genes, so no functional OATP1B3 or OATP1B1 protein is made. Most mutations that cause Rotor syndrome lead to abnormally short, nonfunctioning OATP1B3 and OATP1B1 proteins. Without the function of either transport protein, bilirubin is less efficiently taken up by the liver and cleared from the body. The buildup of this substance leads to jaundice in people with Rotor syndrome.
The SLCO1B3 gene provides instructions for making a protein called organic anion transporting polypeptide 1B3, or OATP1B3. This protein is found in liver cells; it transports compounds from the blood into the liver so that they can be cleared from the body. For example, the OATP1B3 protein transports bilirubin, which is a yellowish substance that is produced when red blood cells are broken down. In the liver, bilirubin is dissolved in a digestive fluid called bile and then excreted from the body. The OATP1B3 protein also transports certain hormones, toxins, and drugs into the liver for removal from the body. Some of the drugs transported by the OATP1B3 protein include statins, which are used to treat high cholesterol; heart disease medications; certain antibiotics; and some drugs used for the treatment of cancer.
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder.
Gene Pathways:
Molecular Function:
- Bile Acid Transmembrane Transporter Activity
- Organic Anion Transmembrane Transporter Activity
- Sodium-Independent Organic Anion Transmembrane Transporter Activity
Biological Processes:
- Bile Acid And Bile Salt Transport
- Bile Acid Metabolic Process
- Organic Anion Transport
- Sodium-Independent Organic Anion Transport
Drug Bank:
- Cobimetinib
- Conjugated Estrogens
- Daclatasvir
- Gadoxetate
- Liothyronine
- Liotrix
- Rifampicin
- Rosuvastatin
- Sacubitril
- Ambrisentan
- Atorvastatin
- Cabazitaxel
- Caspofungin
- Cholic Acid
- Clarithromycin
- Dabrafenib
- Digoxin
- Docetaxel
- Estradiol
- Fluvastatin
- Idelalisib
- Levothyroxine
- Methotrexate
- Mycophenolate Mofetil
- Olmesartan
- Ouabain
- Pioglitazone
- Pitavastatin
- Pravastatin
- Rilpivirine
- Romidepsin
- Selexipag
- Cholecystokinin
- Fexofenadine
- Paclitaxel
- Valsartan