The Function of SLC9A3
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773). Plays an important role in signal transduction.
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Protein names
Recommended name:
Sodium/hydrogen exchanger 3Short name:
+Alternative name(s):
Na(+NHE-3
Solute carrier family 9 member 3
- RS56302516 (SLC9A3) ??
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Top Gene-Substance Interactions
SLC9A3 Interacts with These Diseases
| Disease | Score |
Substances That Increase SLC9A3
| Substances | Interaction | Organism | Category |
Substances That Decrease SLC9A3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Caution:
The number, localization and denomination of hydrophobic domains in the Na(+)/H(+) exchangers vary among authors.
Molecular Function:
Biological Processes:
- Regulation Of Sodium Ion Transport
- Ion Transport
- Receptor-Mediated Endocytosis
- Circadian Rhythm
- Response To Glucocorticoid
- Regulation Of Intracellular Ph
- Potassium Ion Transmembrane Transport
- Sodium Ion Import Across Plasma Membrane