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  3. SLC9A3

SLC9A3 (Solute carrier family 9 member A3)

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The Function of SLC9A3

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773). Plays an important role in signal transduction.

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Protein names

Recommended name:

Sodium/hydrogen exchanger 3

Short name:

+

Alternative name(s):

Na(+
NHE-3
Solute carrier family 9 member 3

SLC9A3 SNPs

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  1. RS56302516 (SLC9A3) ??

Top Gene-Substance Interactions

SLC9A3 Interacts with These Diseases

Disease Score

Substances That Increase SLC9A3

Substances Interaction Organism Category

Substances That Decrease SLC9A3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • AP-1
  • c-Jun
  • STAT3
  • Sp1
  • c-Fos

Gene Pathways:

  • Bile secretion
  • Protein digestion and absorption
  • Proximal tubule bicarbonate reclamation
  • Transmembrane transport of small molecules
  • Mineral absorption

Caution:

The number, localization and denomination of hydrophobic domains in the Na(+)/H(+) exchangers vary among authors.

Molecular Function:

  • Pdz Domain Binding
  • Potassium:Proton Antiporter Activity
  • Sodium:Proton Antiporter Activity

Biological Processes:

  • Ion Transport
  • Potassium Ion Transmembrane Transport
  • Regulation Of Intracellular Ph
  • Sodium Ion Import Across Plasma Membrane
  • Circadian Rhythm
  • Receptor-Mediated Endocytosis
  • Regulation Of Sodium Ion Transport
  • Response To Glucocorticoid
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_09489| Anapl_11803| AS27_05995| AS28_15036| D623_10035820| DIAR8| gill Na+/H+ exchanger| H920_00147| I79_024580| M959_13399| MDA_GLEAN10025843| N300_15285| N301_11925| N302_03202| N303_06795| N305_01768| N306_10965| N310_06660| N320_01984| N321_13274| N322_03275| N324_10154| N326_11945| N327_13626| N328_12197| N329_03370| N330_05987| N331_10588| N332_00871| N333_03027| N334_12438| N335_14539| N336_05000| N339_07837| N340_12196| Na/H exchanger 3| Na(+)/H(+) exchanger 3| Na+/H+ exchanger 3| Na+/H+ exchanger homolog| nhe3| NHE-3| PAL_GLEAN10006359| plasma membrane ion transport protein| SLC9A5| sodium/hydrogen exchanger| Sodium/hydrogen exchanger 3| sodium proton exchanger| solute carrier family 9 member 3| solute carrier family 9 (sodium/hydrogen exchanger)| Solute carrier family 9 (sodium/hydrogen exchanger 3), antiporter 3, Na+/H+ (amiloride insensitive)| solute carrier family 9 (sodium/hydrogen exchanger), member 3| solute carrier family 9, subfamily A (NHE3, cation proton antipo| solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3| solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5| TREES_T100010388| UY3_06214| Y1Q_015280| slc9a3

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