The Function of SLC8A1
Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:1374913, PubMed:11241183, PubMed:1476165). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions.
Protein names
Recommended name:
Sodium/calcium exchanger 1Short name:
2+Alternative name(s):
Na(+Solute carrier family 8 member 1
- RS17025867 (SLC8A1) ??
- RS3749056 (SLC8A1) ??
- RS404005 (SLC8A1) ??
- RS434082 (SLC8A1) ??
- RS4629203 (SLC8A1) ??
- RS6544311 (SLC8A1) ??
- RS6759076 (SLC8A1) ??
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Top Gene-Substance Interactions
SLC8A1 Interacts with These Diseases
| Disease | Score |
Substances That Increase SLC8A1
| Substances | Interaction | Organism | Category |
Substances That Decrease SLC8A1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected primarily in heart and at lower levels in brain (PubMed:1374913). Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung (PubMed:1476165).
Gene Pathways:
- Calcium signaling pathway
- Hemostasis
- Arrhythmogenic right ventricular cardiomyopathy (ARVC)
- Dilated cardiomyopathy
- Hypertrophic cardiomyopathy (HCM)
- Protein digestion and absorption
- Transmembrane transport of small molecules
- Endocrine and other factor-regulated calcium reabsorption
- Mineral absorption
- Cardiac muscle contraction
Enzyme Regulation:
Activated by micromolar levels of Ca(2+).
Molecular Function:
- Ankyrin Binding
- Calcium:Sodium Antiporter Activity
- Calcium Ion Binding
- Cytoskeletal Protein Binding
- Ion Channel Binding
Biological Processes:
- Calcium Ion Export
- Calcium Ion Homeostasis
- Calcium Ion Import
- Calcium Ion Transmembrane Transport
- Calcium Ion Transport Into Cytosol
- Cardiac Muscle Cell Development
- Cardiac Muscle Contraction
- Cell Communication By Electrical Coupling Involved In Cardiac Conduction
- Cellular Response To Caffeine
- Cellular Response To Camp
- Cellular Response To Hypoxia
- Cellular Response To Reactive Oxygen Species
- Cellular Sodium Ion Homeostasis
- Cytosolic Calcium Ion Transport
- Ion Transport
- Membrane Depolarization During Cardiac Muscle Cell Action Potential
- Muscle Contraction
- Negative Regulation Of Cytosolic Calcium Ion Concentration
- Positive Regulation Of Bone Mineralization
- Positive Regulation Of Fibroblast Migration
- Positive Regulation Of The Force Of Heart Contraction
- Regulation Of Cardiac Conduction
- Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling
- Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
- Regulation Of Cell Communication By Electrical Coupling
- Regulation Of Heart Rate
- Regulation Of Sodium Ion Transport
- Regulation Of The Force Of Heart Contraction
- Relaxation Of Cardiac Muscle
- Relaxation Of Smooth Muscle
- Response To Atp
- Response To Glucose
- Response To Hydrogen Peroxide
- Response To Immobilization Stress
- Response To Muscle Stretch
- Response To Nutrient
- Sodium Ion Export
- Sodium Ion Import
- Sodium Ion Transmembrane Transport
- Telencephalon Development
- Vascular Smooth Muscle Contraction
Drug Bank:
- Icosapent
- Alpha-Linolenic Acid