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  3. SLC8A1

SLC8A1 (Solute carrier family 8 member A1)

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The Function of SLC8A1

Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:1374913, PubMed:11241183, PubMed:1476165). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions.

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Protein names

Recommended name:

Sodium/calcium exchanger 1

Short name:

2+

Alternative name(s):

Na(+
Solute carrier family 8 member 1

SLC8A1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS17025867 (SLC8A1) ??
  2. RS3749056 (SLC8A1) ??
  3. RS404005 (SLC8A1) ??
  4. RS434082 (SLC8A1) ??
  5. RS4629203 (SLC8A1) ??
  6. RS6544311 (SLC8A1) ??
  7. RS6759076 (SLC8A1) ??

Top Gene-Substance Interactions

SLC8A1 Interacts with These Diseases

Disease Score

Substances That Increase SLC8A1

Substances Interaction Organism Category

Substances That Decrease SLC8A1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • deltaCREB

Tissue specificity:

Detected primarily in heart and at lower levels in brain (PubMed:1374913). Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung (PubMed:1476165).

Gene Pathways:

  • Calcium signaling pathway
  • Hemostasis
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC)
  • Dilated cardiomyopathy
  • Hypertrophic cardiomyopathy (HCM)
  • Protein digestion and absorption
  • Transmembrane transport of small molecules
  • Endocrine and other factor-regulated calcium reabsorption
  • Mineral absorption
  • Cardiac muscle contraction

Enzyme Regulation:

Activated by micromolar levels of Ca(2+).

Molecular Function:

  • Ankyrin Binding
  • Calcium:Sodium Antiporter Activity
  • Calcium Ion Binding
  • Cytoskeletal Protein Binding
  • Ion Channel Binding

Biological Processes:

  • Calcium Ion Export
  • Calcium Ion Homeostasis
  • Calcium Ion Import
  • Calcium Ion Transmembrane Transport
  • Calcium Ion Transport Into Cytosol
  • Cardiac Muscle Cell Development
  • Cardiac Muscle Contraction
  • Cell Communication By Electrical Coupling Involved In Cardiac Conduction
  • Cellular Response To Caffeine
  • Cellular Response To Camp
  • Cellular Response To Hypoxia
  • Cellular Response To Reactive Oxygen Species
  • Cellular Sodium Ion Homeostasis
  • Cytosolic Calcium Ion Transport
  • Ion Transport
  • Membrane Depolarization During Cardiac Muscle Cell Action Potential
  • Muscle Contraction
  • Negative Regulation Of Cytosolic Calcium Ion Concentration
  • Positive Regulation Of Bone Mineralization
  • Positive Regulation Of Fibroblast Migration
  • Positive Regulation Of The Force Of Heart Contraction
  • Regulation Of Cardiac Conduction
  • Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling
  • Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
  • Regulation Of Cell Communication By Electrical Coupling
  • Regulation Of Heart Rate
  • Regulation Of Sodium Ion Transport
  • Regulation Of The Force Of Heart Contraction
  • Relaxation Of Cardiac Muscle
  • Relaxation Of Smooth Muscle
  • Response To Atp
  • Response To Glucose
  • Response To Hydrogen Peroxide
  • Response To Immobilization Stress
  • Response To Muscle Stretch
  • Response To Nutrient
  • Sodium Ion Export
  • Sodium Ion Import
  • Sodium Ion Transmembrane Transport
  • Telencephalon Development
  • Vascular Smooth Muscle Contraction

Drug Bank:

  • Icosapent
  • Alpha-Linolenic Acid
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_05494| AS27_07510| AS28_12796| AV344025| cardiac sarcolemmal sodium-calcium exchanger| CB1_001677002| D623_10033422| GW7_11585| H920_15305| I79_014629| M91_04057| M959_08192| MDA_GLEAN10015172| N300_05361| N301_02058| N302_08600| N303_01289| N305_14159| N306_11575| N307_07869| N309_09235| N312_07414| N320_02811| N321_11205| N322_05853| N324_09145| N325_09504| N326_11225| N327_10927| N328_05775| N329_06263| N333_05623| N334_01977| N336_00412| N339_09602| N340_10774| N341_12419| NACA| Na(+)/Ca(2+)-exchange protein 1| Na+/Ca2+ exchanger| Na+/Ca2+ exchanger isoform NACA3| Na-Ca exchanger| Na/Ca exchanger| Na+/Ca++ exchanger| Ncx| ncx1| NCX-1| PAL_GLEAN10021317| PANDA_007304| SLC8A1 solute carrier family 8 member 1| sodium-calcium exchanger| sodium/calcium exchanger| sodium/calcium exchanger 1| sodium/calcium exchanger 3| sodium/calcium exchanger isoform NaCa13| sodium/calcium exchanger isoform NaCa3| sodium/calcium exchanger isoform NaCa7| sodium/calcium exchanger isoform NaCa9| sodium-calcium exchanger isoform NCX1.3| solute carrier familiy 8 member 1| solute carrier family 8 , member 1| solute carrier family 8 member 1| solute carrier family 8, member 1| solute carrier family 8 (sodium/calcium exchanger), member 1| TREES_T100007079| UY3_06271| Y1Q_002281| Y956_01967| Z169_08753| slc8a1

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