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  3. SLC7A5

SLC7A5 (Solute carrier family 7 member 5)

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The Function of SLC7A5

Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L-leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts.

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Protein names

Recommended name:

Large neutral amino acids transporter small subunit 1

Short name:

4F2LC

Alternative name(s):

4F2 light chain
4F2 LC
CD98 light chain
Integral membrane protein E16
L-type amino acid transporter 1
hLAT1
Solute carrier family 7 member 5
y+ system cationic amino acid transporter

SLC7A5 SNPs

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  1. RS8051149 (SLC7A5) ??

Top Gene-Substance Interactions

SLC7A5 Interacts with These Diseases

Disease Score

Substances That Increase SLC7A5

Substances Interaction Organism Category

Substances That Decrease SLC7A5

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Pax-3
  • AP-1
  • MEF-2A
  • NF-E2
  • NF-E2 p45
  • Fra-1
  • JunD

Tissue specificity:

Expressed abundantly in adult lung, liver, brain, skeletal muscle, placenta, bone marrow, testis, resting lymphocytes and monocytes, and in fetal liver. Weaker expression in thymus, cornea, retina, peripheral leukocytes, spleen, kidney, colon and lymph node. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Also expressed in all human tumor cell lines tested and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco-2.

Gene Pathways:

  • Hemostasis
  • Transmembrane transport of small molecules
  • Amino acid and oligopeptide SLC transporters

Induction:

Expression induced in quiescent peripheral blood lymphocytes after treatment with phorbol myristate acetate (PMA) and phytohemagglutinin (PHA). Expression and the uptake of leucine is stimulated in mononuclear, cytotrophoblast-like choriocarcinoma cells by combined treatment with PMA and calcium ionophore.

Molecular Function:

  • Amino Acid Transmembrane Transporter Activity
  • Antiporter Activity
  • L-Amino Acid Transmembrane Transporter Activity
  • Neutral Amino Acid Transmembrane Transporter Activity
  • Peptide Antigen Binding

Biological Processes:

  • Amino Acid Transport
  • Cell Differentiation
  • Cellular Amino Acid Metabolic Process
  • Leukocyte Migration
  • Nervous System Development
  • Neutral Amino Acid Transport
  • Transport

Drug Bank:

  • Liothyronine
  • Levodopa
  • Melphalan
  • Dextrothyroxine
  • Levothyroxine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| LAT1| 4F2LC| 4F2 LC| 4F2 light chain| A306_01714| Anapl_14366| AS27_11350| AS28_10208| blood-brain barrier large neutral amino acid transporter light chain| CD98| CD98 light chain| D0H16S474E| D16S469E| D623_10035278| E16| H920_06739| hlat1| integral membrane protein E16| JHI-21| L amino acid transporter-1| Large neutral amino acids transporter small subunit 1| large neutral amino acids transporter small subunit 1-like protein| LAT-1| LAT1 light chain| L-type amino acid transporter 1| L-type amino acid transporter subunit| M91_08302| M959_05405| MDA_GLEAN10022612| MPE16| N300_09170| N301_00335| N302_09632| N303_10627| N305_04803| N306_00357| N307_03660| N309_06035| N310_02493| N311_12618| N320_07317| N321_01144| N325_04490| N326_02168| N327_09173| N328_07106| N329_04407| N330_10308| N332_13536| N334_07178| N339_08388| N340_10210| N341_05182| PAL_GLEAN10025633| PANDA_001226| slc7a5-a| slc7a5-b| sodium-independent neutral amino acid transporter LAT1| solute carrier family 7 (amino acid transporter light chain, L s| solute carrier family 7 (amino acid transporter light chain, L system), member 5| solute carrier family 7 (cationic amino acid transporter, y+ system), member 5| solute carrier family 7 , member 5| TA1| TA1/LAT-1/CD98 light chain region| tumor-associated protein 1| Y1Q_020625| Y956_11001| slc7a5

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