The Function of SLC7A5
Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L-leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts.
Protein names
Recommended name:
Large neutral amino acids transporter small subunit 1Short name:
4F2LCAlternative name(s):
4F2 light chain4F2 LC
CD98 light chain
Integral membrane protein E16
L-type amino acid transporter 1
hLAT1
Solute carrier family 7 member 5
y+ system cationic amino acid transporter
- RS8051149 (SLC7A5) ??
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Top Gene-Substance Interactions
SLC7A5 Interacts with These Diseases
| Disease | Score |
Substances That Increase SLC7A5
| Substances | Interaction | Organism | Category |
Substances That Decrease SLC7A5
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed abundantly in adult lung, liver, brain, skeletal muscle, placenta, bone marrow, testis, resting lymphocytes and monocytes, and in fetal liver. Weaker expression in thymus, cornea, retina, peripheral leukocytes, spleen, kidney, colon and lymph node. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Also expressed in all human tumor cell lines tested and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco-2.
Gene Pathways:
Induction:
Expression induced in quiescent peripheral blood lymphocytes after treatment with phorbol myristate acetate (PMA) and phytohemagglutinin (PHA). Expression and the uptake of leucine is stimulated in mononuclear, cytotrophoblast-like choriocarcinoma cells by combined treatment with PMA and calcium ionophore.
Molecular Function:
- Amino Acid Transmembrane Transporter Activity
- Antiporter Activity
- L-Amino Acid Transmembrane Transporter Activity
- Neutral Amino Acid Transmembrane Transporter Activity
- Peptide Antigen Binding
Biological Processes:
- Amino Acid Transport
- Cell Differentiation
- Cellular Amino Acid Metabolic Process
- Leukocyte Migration
- Nervous System Development
- Neutral Amino Acid Transport
- Transport
Drug Bank:
- Liothyronine
- Levodopa
- Melphalan
- Dextrothyroxine
- Levothyroxine