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  3. SLC6A4

SLC6A4 (Solute carrier family 6 member 4)

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Summary of SLC6A4

This gene encodes a membrane protein that transports serotonin to presynaptic neurons. It is a target of psychomotor stimulant. Polymorphisms of this gene may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression (R). 

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The Function of SLC6A4

Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.

Protein names

Recommended name:

Sodium-dependent serotonin transporter

Short name:

SERT

Alternative name(s):

5HT transporter
5HTT
Solute carrier family 6 member 4

SLC6A4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1042173 (SLC6A4) ??
  2. RS11867581 (SLC6A4) ??
  3. RS140700 (SLC6A4) ??
  4. RS140701 (SLC6A4) ??
  5. RS2020933 (SLC6A4) ??
  6. RS2020934 (SLC6A4) ??
  7. RS2020936 (SLC6A4) ??
  8. RS2020942 (SLC6A4) ??
  9. RS2066713 (SLC6A4) ??
  10. RS2129785 (SLC6A4) ??
  11. RS25531 (SLC6A4) ??
  12. RS3794808 (SLC6A4) ??
  13. RS4251417 (SLC6A4) ??
  14. RS6354 (SLC6A4) ??

Top Gene-Substance Interactions

SLC6A4 Interacts with These Diseases

Disease Score

Substances That Increase SLC6A4

Substances Interaction Organism Category

Substances That Decrease SLC6A4

Substances Interaction Organism Category

Advanced Summary

Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization.

Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.

From NCBI Gene:

  • Anxiety
  • Obsessive-compulsive disorder

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons.

The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner.

This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family.

A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • GR
  • GR-alpha
  • GR-beta
  • NF-kappaB1
  • C/EBPalpha

Tissue specificity:

Expressed in platelets (at protein level).

Induction:

Down-regulated when plasma serotonin is elevated.

Molecular Function:

  • Actin Filament Binding
  • Cocaine Binding
  • Metal Ion Binding
  • Monoamine Transmembrane Transporter Activity
  • Rab Gtpase Binding
  • Serotonin:Sodium Symporter Activity
  • Serotonin Transmembrane Transporter Activity

Biological Processes:

  • Brain Morphogenesis
  • Cellular Response To Cgmp
  • Cellular Response To Retinoic Acid
  • Chemical Synaptic Transmission
  • Circadian Rhythm
  • Memory
  • Monoamine Transport
  • Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation
  • Negative Regulation Of Neuron Differentiation
  • Negative Regulation Of Organ Growth
  • Negative Regulation Of Synaptic Transmission, Dopaminergic
  • Positive Regulation Of Cell Cycle
  • Positive Regulation Of Gene Expression
  • Protein Homooligomerization
  • Protein Oligomerization
  • Response To Estradiol
  • Response To Hypoxia
  • Response To Nutrient
  • Response To Toxic Substance
  • Serotonin Transport
  • Serotonin Uptake
  • Social Behavior
  • Sperm Ejaculation
  • Thalamus Development
  • Vasoconstriction

Drug Bank:

  • Atomoxetine
  • Chlorphenamine
  • Desvenlafaxine
  • Dexmethylphenidate
  • Duloxetine
  • Ephedra
  • Levomilnacipran
  • Pethidine
  • Vilazodone
  • Amphetamine
  • Butriptyline
  • Citalopram
  • Clomipramine
  • Cocaine
  • Desipramine
  • Dextromethorphan
  • Dopamine
  • Doxepin
  • Escitalopram
  • Fluoxetine
  • Fluvoxamine
  • Loxapine
  • Mazindol
  • Methamphetamine
  • Methylphenidate
  • Mianserin
  • Milnacipran
  • Mirtazapine
  • Nefazodone
  • Nortriptyline
  • Paroxetine
  • Protriptyline
  • Pseudoephedrine
  • Sertraline
  • Sibutramine
  • Tapentadol
  • Tramadol
  • Trimipramine
  • Venlafaxine
  • Verapamil
  • Vortioxetine
  • Amitriptyline
  • Amoxapine
  • Dexfenfluramine
  • Imipramine
  • Minaprine
  • Phentermine
  • Trazodone
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| solute carrier family 6 (neurotransmitter transporter, serotonin), member 4| 5HTT| 5-HTT| 5-HTTLPR| 5HT transporter| 5-hydroxytryptamine (serotonin) transporter| A306_15787| AS27_13454| AS28_08332| CB1_000765109| D623_10015938| H920_13052| hSERT| HTT| I79_013361| M91_14659| M959_13539| MDA_GLEAN10016850| N300_03520| N301_15243| N302_07756| N303_12416| N305_15131| N306_03497| N307_07421| N308_07074| N309_13276| N311_06873| N312_01506| N320_01686| N321_13573| N322_13256| N324_02210| N325_04336| N326_07361| N327_09371| N328_00841| N329_06354| N330_05134| N331_12327| N332_00664| N333_05791| N334_03933| N335_10140| N336_03290| N339_12194| N340_08911| N341_09056| Na+/Cl- dependent serotonin transporter| OCD1| PAL_GLEAN10019976| PANDA_000079| plasma membrane transporter for serotonin reuptake| serotnin transporter| serotonin transporter| serotonin transporter 1| Sert| SERT1| Sodium-dependent serotonin transporter| Sodium-dependent serotonin transporter (5HT transporter) (5HTT)| solute carrier family 6 (neurotransmitter transporter), member 4| solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter)| Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter)| transmembrane 5-HT transporter| TREES_T100008248| UY3_05065| Y1Q_026717| Y956_11600| Z169_00884| slc6a4

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