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  3. SLC5A8

SLC5A8 (Solute carrier family 5 member 8)

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The Function of SLC5A8

Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.

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Protein names

Recommended name:

Sodium-coupled monocarboxylate transporter 1

Alternative name(s):

Apical iodide transporter
Electrogenic sodium monocarboxylate cotransporter
Sodium iodide-related cotransporter
Solute carrier family 5 member 8

Top Gene-Substance Interactions

Substances That Increase SLC5A8

Substances Interaction Organism Category

Substances That Decrease SLC5A8

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53

Tissue specificity:

Expressed in normal thyroid, localized at the apical pole of thyroid cells facing the colloid lumen, but expression profoundly decreased in thyroid carcinomas. Expressed in normal colon but absent in colon aberrant crypt foci and colon cancers. Present in normal kidney cortex, brain, prostate, gastric mucosa and breast tissue but was significantly down-regulated in primary gliomas, gastric cancer, prostate tumors and breast tumors.

Gene Pathways:

  • Transmembrane transport of small molecules
  • Amino acid and oligopeptide SLC transporters

Induction:

Down-regulated in some primary cancers; due to aberrant methylation in primary colon cancers, astrocytomas and oligodendrogliomas as well as in cancers of the colon, prostate and gastric regions, and glial cell lines. Expression reactivated on treatment with a demethylating drug, 5-azacytidine.

Molecular Function:

  • Monocarboxylic Acid Transmembrane Transporter Activity
  • Passive Transmembrane Transporter Activity
  • Symporter Activity

Biological Processes:

  • Apoptotic Process
  • Ion Transport
  • Sodium Ion Transport

Drug Bank:

  • Gabapentin Enacarbil
  • Niacin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AIT| apical iodide transporter| apical iodide transporter , putative| CB1_002098008| electrogenic sodium monocarboxylate cotransporter| H920_08331| I79_005838| M91_17015| MDA_GLEAN10021948| N308_05196| N310_10052| N312_13061| N320_00727| N321_13906| N322_01033| N324_11995| N326_09654| N328_03627| N330_13404| N331_11225| N332_07357| N335_00747| N336_11541| N339_11882| N341_11232| PAL_GLEAN10015495| RGD1564146| SLC5A6| SMCT| smct1| SMCT1a| SMCT1b| sodium-coupled monocarboxylate 1b splicing isoform| sodium-coupled monocarboxylate cotransporter 1| sodium-coupled monocarboxylate transporter 1| sodium-coupled monocarboxylate transporter 1b| sodium-dependent monocarboxylate cotransporter| sodium iodide-related cotransporter| sodium monocarboxylate transporter 1| solute carrier family 5A member 8| solute carrier family 5 (iodide transporter), member 8| solute carrier family 5 (sodium/monocarboxylate cotransporter)| solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8| TREES_T100002514| UY3_16052| vito| Y1Q_030525| slc5a8

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