The Function of SLC46A1
Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme.
Protein names
Recommended name:
Proton-coupled folate transporterShort name:
G21Alternative name(s):
Heme carrier protein 1PCFT/HCP1
Solute carrier family 46 member 1
Top Gene-Substance Interactions
SLC46A1 Interacts with These Diseases
| Disease | Score |
Substances That Increase SLC46A1
| Substances | Interaction | Organism | Category |
Substances That Decrease SLC46A1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in kidney, liver, placenta, small intestine, spleen, retina and retinal pigment epithelium. Lower levels found in colon and testis. Very low levels in brain, lung, stomach, heart and muscle. In intestine, expressed in duodenum with lower levels in jejunum, ileum, cecum, rectum and segments of the colon.
Gene Pathways:
Molecular Function:
- Folic Acid Binding
- Folic Acid Transporter Activity
- Heme Transporter Activity
- Hydrogen Ion Transmembrane Transporter Activity
- Methotrexate Transporter Activity
Biological Processes:
- Cellular Iron Ion Homeostasis
- Folic Acid Import Into Cell
- Folic Acid Metabolic Process
- Folic Acid Transport
- Hydrogen Ion Transmembrane Transport
- Intestinal Folate Absorption
- Methotrexate Transport