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  3. SLC46A1

SLC46A1 (Solute carrier family 46 member 1)

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The Function of SLC46A1

Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme.

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Protein names

Recommended name:

Proton-coupled folate transporter

Short name:

G21

Alternative name(s):

Heme carrier protein 1
PCFT/HCP1
Solute carrier family 46 member 1

Top Gene-Substance Interactions

SLC46A1 Interacts with These Diseases

Disease Score

Substances That Increase SLC46A1

Substances Interaction Organism Category

Substances That Decrease SLC46A1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • CUTL1
  • PPAR-gamma2
  • PPAR-alpha
  • ARP-1
  • GATA-1
  • E47
  • Gfi-1

Tissue specificity:

Expressed in kidney, liver, placenta, small intestine, spleen, retina and retinal pigment epithelium. Lower levels found in colon and testis. Very low levels in brain, lung, stomach, heart and muscle. In intestine, expressed in duodenum with lower levels in jejunum, ileum, cecum, rectum and segments of the colon.

Gene Pathways:

  • Metabolism
  • Disease
  • Transmembrane transport of small molecules
  • Mineral absorption
  • Vitamin digestion and absorption

Molecular Function:

  • Folic Acid Binding
  • Folic Acid Transporter Activity
  • Heme Transporter Activity
  • Hydrogen Ion Transmembrane Transporter Activity
  • Methotrexate Transporter Activity

Biological Processes:

  • Cellular Iron Ion Homeostasis
  • Folic Acid Import Into Cell
  • Folic Acid Metabolic Process
  • Folic Acid Transport
  • Hydrogen Ion Transmembrane Transport
  • Intestinal Folate Absorption
  • Methotrexate Transport

Drug Bank:

  • Folic Acid
  • Methotrexate
  • Sulfasalazine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| HCP1| A306_15751| AS27_13419| AS28_11761| CB1_000765076| D11Ertd18e| D623_10015984| G21| GW7_08172| H920_13088| heme carrier protein 1| M959_13415| MDA_GLEAN10016811| N300_03488| N301_12377| N302_16368| N303_12144| N305_15095| N306_10485| N307_07386| N308_00553| N309_08286| N310_07072| N320_06121| N321_00728| N322_10005| N326_07548| N327_08404| N328_08771| N329_02898| N332_05759| N333_04120| N334_05129| N340_13459| PAL_GLEAN10019928| PANDA_000122| Pcft| PCFT/HCP1| proton-coupled folate transporter| retinal pigment epithelilum transporter| retinal pigment epithelium transporter| RGD1309472| solute carrier family 46 (folate transporter), member 1| solute carrier family 46 , member 1| solute carrier family 46, member 1| TREES_T100003582| TRPE| Y1Q_009700| Y956_14715| slc46a1

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