Summary of SLC39A8
The gene codes for a protein, solute carrier family 39 member 8. It plays a role in the cellular import of zinc at the onset of inflammation. It is the primary transporter of the toxic cation cadmium, which is found in cigarette smoke [R].
The Function of SLC39A8
Acts as a manganese and zinc influx transporter (PubMed:12504855, PubMed:26637978). Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain (PubMed:26637978).
Protein names
Recommended name:
Zinc transporter ZIP8Short name:
ZIP-8Alternative name(s):
BCG-induced integral membrane protein in monocyte clone 103 proteinLIV-1 subfamily of ZIP zinc transporter 6
LZT-Hs6
Solute carrier family 39 member 8
Zrt- and Irt-like protein 8
- RS13107325 (SLC39A8) ??
- RS13135092 (SLC39A8) ??
- RS233817 (SLC39A8) ??
- RS35518360 (SLC39A8) ??
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Top Gene-Substance Interactions
Substances That Increase SLC39A8
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Substances That Decrease SLC39A8
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Advanced Summary
From NCBI Gene: CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIn
From NCBI Gene: This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008] From UniProt: Acts as a zinc-influx transporter.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas.
Gene Pathways:
Induction:
By live and heat-killed Mycobacterium bovis bacterial cell wall and inflammatory cytokines like TNF. Down-regulated following phorbol ester treatment.
Molecular Function:
Biological Processes:
- Cadmium Ion Transmembrane Transport
- Cellular Zinc Ion Homeostasis
- Zinc Ii Ion Transmembrane Import
- Zinc Ii Ion Transport