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  3. SLC39A8

SLC39A8 (Solute carrier family 39 member 8)

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Summary of SLC39A8

The gene codes for a protein, solute carrier family 39 member 8. It plays a role in the cellular import of zinc at the onset of inflammation. It is the primary transporter of the toxic cation cadmium, which is found in cigarette smoke [R].

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The Function of SLC39A8

Acts as a manganese and zinc influx transporter (PubMed:12504855, PubMed:26637978). Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain (PubMed:26637978).

Protein names

Recommended name:

Zinc transporter ZIP8

Short name:

ZIP-8

Alternative name(s):

BCG-induced integral membrane protein in monocyte clone 103 protein
LIV-1 subfamily of ZIP zinc transporter 6
LZT-Hs6
Solute carrier family 39 member 8
Zrt- and Irt-like protein 8

SLC39A8 SNPs

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  1. RS13107325 (SLC39A8) ??
  2. RS13135092 (SLC39A8) ??
  3. RS233817 (SLC39A8) ??
  4. RS35518360 (SLC39A8) ??

Top Gene-Substance Interactions

Substances That Increase SLC39A8

Substances Interaction Organism Category

Substances That Decrease SLC39A8

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIn

     From NCBI Gene: This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008] From UniProt: Acts as a zinc-influx transporter.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • HNF-1A
  • CREB
  • deltaCREB
  • HNF-1
  • c-Myc
  • c-Myb
  • FOXL1
  • HFH-1

Tissue specificity:

Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas.

Gene Pathways:

  • Transmembrane transport of small molecules

Induction:

By live and heat-killed Mycobacterium bovis bacterial cell wall and inflammatory cytokines like TNF. Down-regulated following phorbol ester treatment.

Molecular Function:

  • Zinc Ion Transmembrane Transporter Activity

Biological Processes:

  • Cadmium Ion Transmembrane Transport
  • Cellular Zinc Ion Homeostasis
  • Zinc Ii Ion Transmembrane Import
  • Zinc Ii Ion Transport
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_15883| Anapl_11275| AS28_14628| BCG induced integral membrane protein BIGM103| BCG-induced integral membrane protein in monocyte clone 103 protein| BIGM103| CB1_001060008| CDG2N| D623_10013136| EGK_15970| EH28_07943| GW7_16951| H920_12799| I79_025000| LIV-1 subfamily of ZIP zinc transporter 6| LZT-Hs6| M959_04174| MDA_GLEAN10016926| N300_02247| N301_12590| N302_04227| N303_14119| N305_00585| N306_02885| N307_10765| N308_06609| N309_10410| N310_01798| N311_09866| N312_07443| N320_10536| N322_10302| N325_10367| N326_01499| N327_02885| N328_02218| N329_08931| N330_05326| N331_05889| N332_04844| N333_11798| N334_12050| N335_10100| N336_03624| N339_00086| N340_00816| N341_04233| PAL_GLEAN10022569| PANDA_004618| PP3105| solute carrier family 39 , member 8| solute carrier family 39 (metal ion transporter), member 8| solute carrier family 39 (metal ion transporter), member 8-like protein| solute carrier family 39 (zinc transporter), member 8| solute carrier family 39 (zinc transporter), member 8 tv2| TREES_T100004028| UY3_10090| Y1Q_012423| Y956_00944| Z169_14860| Zinc transporter ZIP8| zinc transporter ZIP8-like protein| ZIP8| ZIP-8| Zrt- and Irt-like protein 8| slc39a8

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