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SLC39A4 (Solute carrier family 39 member 4)

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Summary of SLC39A4

The gene codes for a protein, solute carrier family 39 member 4. Mutations cause acrodermatitis enteropathica [R].

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The Function of SLC39A4

Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability.

Protein names

Recommended name:

Zinc transporter ZIP4

Short name:

ZIP-4

Alternative name(s):

Solute carrier family 39 member 4
Zrt- and Irt-like protein 4

SLC39A4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2280838 (SLC39A4) ??
  2. RS2977838 (SLC39A4) ??

Top Gene-Substance Interactions

SLC39A4 Interacts with These Diseases

Disease Score

Substances That Increase SLC39A4

Substances Interaction Organism Category

Substances That Decrease SLC39A4

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Hereditary acrodermatitis enteropathicaFrom UniProt: Acrodermatitis enteropathica, zinc-deficiency type (AEZ): A rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinical features are growth retardation, immune-system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. [MIM:201100]

     From NCBI Gene: This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013] From UniProt: Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GATA-1
  • SREBP-1a
  • GATA-2
  • GATA-3
  • LCR-F1
  • GCNF

Tissue specificity:

Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum.

Gene Pathways:

  • Transmembrane transport of small molecules
  • Mineral absorption

Molecular Function:

  • Zinc Ion Transmembrane Transporter Activity

Biological Processes:

  • Cellular Response To Zinc Ion Starvation
  • Cellular Zinc Ion Homeostasis
  • Zinc Ii Ion Transmembrane Import
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| activated in W/Wv mouse stomach 2| AEZ| AWMS2| GW7_19233| H920_08002| M91_08892| mAWMS2| PAL_GLEAN10010497| SLC39A12| solute carrier family 39 (zinc transporter), member 4| TREES_T100007991| UY3_15724| Zinc transporter ZIP4| zinc transporter ZIP4-like protein| zip4| ZIP-4| zrt- and Irt-like protein 4| slc39a4

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