Summary of SLC39A4
The gene codes for a protein, solute carrier family 39 member 4. Mutations cause acrodermatitis enteropathica [R].
The Function of SLC39A4
Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability.
Protein names
Recommended name:
Zinc transporter ZIP4Short name:
ZIP-4Alternative name(s):
Solute carrier family 39 member 4Zrt- and Irt-like protein 4
- RS2280838 (SLC39A4) ??
- RS2977838 (SLC39A4) ??
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Top Gene-Substance Interactions
SLC39A4 Interacts with These Diseases
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Substances That Increase SLC39A4
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Substances That Decrease SLC39A4
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Advanced Summary
From NCBI Gene: Hereditary acrodermatitis enteropathicaFrom UniProt: Acrodermatitis enteropathica, zinc-deficiency type (AEZ): A rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinical features are growth retardation, immune-system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. [MIM:201100]
From NCBI Gene: This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013] From UniProt: Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum.
Gene Pathways:
Molecular Function:
Biological Processes:
- Cellular Response To Zinc Ion Starvation
- Cellular Zinc Ion Homeostasis
- Zinc Ii Ion Transmembrane Import