Disease	Score

Substances	Interaction	Organism	Category

Substances	Interaction	Organism	Category

     From NCBI Gene: Hereditary acrodermatitis enteropathicaFrom UniProt: Acrodermatitis enteropathica, zinc-deficiency type (AEZ): A rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinical features are growth retardation, immune-system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. [MIM:201100]

     From NCBI Gene: This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013] From UniProt: Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability.

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

The following transcription factors affect gene expression:

• GATA-1
• SREBP-1a
• GATA-2
• GATA-3
• LCR-F1
• GCNF

Tissue specificity:

Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum.

Molecular Function:

• Zinc Ion Transmembrane Transporter Activity

Biological Processes:

• Cellular Zinc Ion Homeostasis
• Cellular Response To Zinc Ion Starvation
• Zinc Ii Ion Transmembrane Import

*synonyms