The Function of SLC37A4
Inorganic phosphate and glucose-6-phosphate antiporter of the endoplasmic reticulum. Transports cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocates inorganic phosphate into the opposite direction. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels.
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Protein names
Recommended name:
Glucose-6-phosphate exchanger SLC37A4Short name:
TRG-19Alternative name(s):
Glucose-5-phosphate transporterGlucose-6-phosphate translocase
Solute carrier family 37 member 4
Transformation-related gene 19 protein
- RS10892324 (SLC37A4) ??
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Top Gene-Substance Interactions
SLC37A4 Interacts with These Diseases
| Disease | Score |
Substances That Increase SLC37A4
| Substances | Interaction | Organism | Category |
Substances That Decrease SLC37A4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Mostly expressed in liver and kidney.
Gene Pathways:
Enzyme Regulation:
Inhibited by vanadate and chlorogenic acid.
Molecular Function:
- Transporter Activity
- Glucose-6-Phosphate Transmembrane Transporter Activity
- Glucose 6-Phosphate:Inorganic Phosphate Antiporter Activity
Biological Processes:
- Positive Regulation Of Defense Response To Virus By Host
- Glucose Metabolic Process
- Transport
- Glucose Transport
- Glucose-6-Phosphate Transport
- Phosphate Ion Transmembrane Transport
- Glucose Homeostasis
- Mitophagy In Response To Mitochondrial Depolarization
- Xenophagy