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  3. SLC37A4

SLC37A4 (Solute carrier family 37 member 4)

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The Function of SLC37A4

Inorganic phosphate and glucose-6-phosphate antiporter of the endoplasmic reticulum. Transports cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocates inorganic phosphate into the opposite direction. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels.

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Protein names

Recommended name:

Glucose-6-phosphate exchanger SLC37A4

Short name:

TRG-19

Alternative name(s):

Glucose-5-phosphate transporter
Glucose-6-phosphate translocase
Solute carrier family 37 member 4
Transformation-related gene 19 protein

SLC37A4 SNPs

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  1. RS10892324 (SLC37A4) ??

Top Gene-Substance Interactions

SLC37A4 Interacts with These Diseases

Disease Score

Substances That Increase SLC37A4

Substances Interaction Organism Category

Substances That Decrease SLC37A4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1
  • GR
  • GR-alpha
  • PPAR-alpha
  • c-Myc
  • Meis-1
  • GATA-1

Tissue specificity:

Mostly expressed in liver and kidney.

Gene Pathways:

  • Metabolism
  • Disease
  • Transmembrane transport of small molecules
  • Carbohydrate digestion and absorption

Enzyme Regulation:

Inhibited by vanadate and chlorogenic acid.

Molecular Function:

  • Glucose 6-Phosphate:Inorganic Phosphate Antiporter Activity
  • Glucose-6-Phosphate Transmembrane Transporter Activity
  • Transporter Activity

Biological Processes:

  • Glucose-6-Phosphate Transport
  • Glucose Homeostasis
  • Glucose Metabolic Process
  • Glucose Transport
  • Phosphate Ion Transmembrane Transport
  • Transport
  • Mitophagy In Response To Mitochondrial Depolarization
  • Positive Regulation Of Defense Response To Virus By Host
  • Xenophagy
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 100043178| Anapl_06756| AS27_04216| AS28_14552| CB1_000200027| G6PC| G6PT| g6pt1| g6pt2| G6PT3| glucose-5-phosphate transporter| glucose-6-phosphatase, catalytic subunit| glucose-6-phosphatase, transport (glucose-6-phosphate) protein 1| glucose-6-phosphatase, transport (glucose) protein 3| glucose-6-phosphatase, transport (phosphate/pyrophosphate) protein 2| glucose-6-phosphatase, transport protein 1| glucose-6-phosphate exchanger SLC37A4| Glucose-6-phosphate translocase| Glucose 6-phosphate translocase isoform 3-like protein| glucose 6-phosphate transporter| GSD1b| GSD-1b| GSD1c| GSD1d| GW7_18676| H920_07496| I79_020109| M959_12507| MDA_GLEAN10008963| mG6PT| microsomal glucose-6-phosphate transporter| N300_01397| N301_03737| N302_11197| N303_10868| N305_04191| N306_01814| N307_12560| N308_03382| N309_03918| N321_09073| N322_06424| N325_10424| N327_05516| N328_09578| N329_08894| N330_09579| N331_10794| N332_11191| N334_11503| N336_06738| N339_01277| N340_04406| PAL_GLEAN10001974| PANDA_019877| pro0685| solute carrier family 37 (glucose-6-phosphate transporter), memb| solute carrier family 37 (glucose-6-phosphate transporter), member 4| solute carrier family 37 (glycerol-6-phosphate transporter), member 4| solute carrier family 37 , member 4| transformation-related gene 19 protein| transporter| TREES_T100013277| trg19| TRG-19| UY3_09475| Y1Q_017865| Y956_00864| Z169_16049| slc37a4

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