The Function of SLC2A5
Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake.
Protein names
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 5Short name:
GLUT-5Alternative name(s):
Fructose transporterGlucose transporter type 5, small intestine
- RS11121321 (SLC2A5) ??
- RS12080794 (SLC2A5) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
Substances That Increase SLC2A5
| Substances | Interaction | Organism | Category |
Substances That Decrease SLC2A5
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in skeletal muscle, and in jejunum brush border membrane and basolateral membrane (at protein level) (PubMed:7619085). Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue.
Gene Pathways:
Induction:
By forskolin in Caco-2 cells.
Enzyme Regulation:
The uptake of 2-deoxyglucose is inhibited by cytochalasin B.
Molecular Function:
- Fructose Binding
- Fructose Transmembrane Transporter Activity
- Glucose Transmembrane Transporter Activity
Biological Processes:
- Carbohydrate Metabolic Process
- Cellular Response To Fructose Stimulus
- Fructose Import Across Plasma Membrane
- Fructose Transport
- Glucose Transport
- Hexose Transport
- Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal
- Response To Fructose