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  3. SLC2A5

SLC2A5 (Solute carrier family 2 member 5)

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The Function of SLC2A5

Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake.

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Protein names

Recommended name:

Solute carrier family 2, facilitated glucose transporter member 5

Short name:

GLUT-5

Alternative name(s):

Fructose transporter
Glucose transporter type 5, small intestine

SLC2A5 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11121321 (SLC2A5) ??
  2. RS12080794 (SLC2A5) ??

Top Gene-Substance Interactions

Substances That Increase SLC2A5

Substances Interaction Organism Category

Substances That Decrease SLC2A5

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • AP-1
  • RORalpha2
  • Brachyury
  • Lmo2
  • E47
  • GCNF

Tissue specificity:

Detected in skeletal muscle, and in jejunum brush border membrane and basolateral membrane (at protein level) (PubMed:7619085). Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue.

Gene Pathways:

  • Metabolism
  • Disease
  • Transmembrane transport of small molecules
  • Carbohydrate digestion and absorption

Induction:

By forskolin in Caco-2 cells.

Enzyme Regulation:

The uptake of 2-deoxyglucose is inhibited by cytochalasin B.

Molecular Function:

  • Fructose Binding
  • Fructose Transmembrane Transporter Activity
  • Glucose Transmembrane Transporter Activity

Biological Processes:

  • Carbohydrate Metabolic Process
  • Cellular Response To Fructose Stimulus
  • Fructose Import Across Plasma Membrane
  • Fructose Transport
  • Glucose Transport
  • Hexose Transport
  • Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal
  • Response To Fructose
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_13017| AS28_08700| D623_10021959| fb58f04| fructose transporter| glucose transporter 5| glucose transporter-like protein 5| glucose transporter type 5, small intestine| Glut5| GLUT-5| GLUT5 fructose transporter| GW7_09134| I79_024216| M959_03336| MDA_GLEAN10024410| N300_05996| N301_11377| N303_05194| N307_01468| N310_11538| N311_04566| N321_04532| N331_13070| N334_03071| N336_06503| N340_03738| N341_13058| PAL_GLEAN10013036| slc2a7| Slc5a| solute carrier family 2 (facilitated glucose/fructose transporte| solute carrier family 2 (facilitated glucose/fructose transporter), member 5| solute carrier family 2 (facilitated glucose transporter), member 5| solute carrier family 2, facilitated glucose transporter member 5| solute carrier family 2 (facilitated glucose transporter), member 7| Solute carrier family 2, facilitated glucose transporter member 9| testicular tissue protein Li 81| UY3_01252| Y1Q_018845| zglut5| slc2a5

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