Summary of SLC28A1
This gene encodes proteins that help the transport of glucose and other sugars, bile salts and organic acids, and metal ions (R).
The Function of SLC28A1
Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine.
Protein names
Recommended name:
Sodium/nucleoside cotransporter 1Alternative name(s):
Concentrative nucleoside transporter 1CNT 1
hCNT1
Na(+
Sodium-coupled nucleoside transporter 1
Solute carrier family 28 member 1
- RS2242046 (SLC28A1) ??
- RS2242047 (SLC28A1) ??
- RS2242048 (SLC28A1) ??
- RS2290272 (SLC28A1) ??
- RS3743162 (SLC28A1) ??
- RS7182385 (SLC28A1) ??
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Top Gene-Substance Interactions
SLC28A1 Interacts with These Diseases
| Disease | Score |
Substances That Increase SLC28A1
| Substances | Interaction | Organism | Category |
Substances That Decrease SLC28A1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in kidney.
Gene Pathways:
Molecular Function:
- Nucleoside:Sodium Symporter Activity
- Nucleoside Transmembrane Transporter Activity
- Pyrimidine- And Adenine-Specific:Sodium Symporter Activity