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  3. SLC28A1

SLC28A1 (Solute carrier family 28 member 1)

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Summary of SLC28A1

This gene encodes proteins that help the transport of glucose and other sugars, bile salts and organic acids, and metal ions (R). 

0 users want this gene increased, 0 users want it decreased

The Function of SLC28A1

Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine.

Protein names

Recommended name:

Sodium/nucleoside cotransporter 1

Alternative name(s):

Concentrative nucleoside transporter 1
CNT 1
hCNT1
Na(+
Sodium-coupled nucleoside transporter 1
Solute carrier family 28 member 1

SLC28A1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2242046 (SLC28A1) ??
  2. RS2242047 (SLC28A1) ??
  3. RS2242048 (SLC28A1) ??
  4. RS2290272 (SLC28A1) ??
  5. RS3743162 (SLC28A1) ??
  6. RS7182385 (SLC28A1) ??

Top Gene-Substance Interactions

SLC28A1 Interacts with These Diseases

Disease Score

Substances That Increase SLC28A1

Substances Interaction Organism Category

Substances That Decrease SLC28A1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • C/EBPalpha
  • STAT1
  • STAT1beta
  • STAT1alpha

Tissue specificity:

Expressed in kidney.

Gene Pathways:

  • Transmembrane transport of small molecules

Molecular Function:

  • Nucleoside:Sodium Symporter Activity
  • Nucleoside Transmembrane Transporter Activity
  • Pyrimidine- And Adenine-Specific:Sodium Symporter Activity

Biological Processes:

  • Nucleobase-Containing Compound Metabolic Process
  • Nucleoside Transport

Drug Bank:

  • Zidovudine
  • Gemcitabine
  • Stavudine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| CB1_001815041| CNT1| CNT 1| concentrative nucleoside transporter 1| EGK_17786| H920_03999| HCNT1| I79_020270| MDA_GLEAN10004448| N303_05772| N307_02120| N309_05624| N324_03376| N326_04297| N330_10404| N331_03977| N332_07474| N334_10195| N340_05343| Na/nucleoside cotransporter| Na(+)/nucleoside cotransporter 1| PAL_GLEAN10009529| PANDA_008511| PKCNT1| slc28a2| sodium-coupled nucleoside transporter 1| Sodium/nucleoside cotransporter 1| Sodium/nucleoside cotransporter 2| solute carrier family 28 (concentrative nucleoside transporter), member 1| solute carrier family 28 (concentrative nucleoside transporter), member 2| solute carrier family 28 (sodium-coupled nucleoside transporter), member 1| TREES_T100018748| Y956_15168| slc28a1

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