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  3. SLC22A18

SLC22A18 (Solute carrier family 22 member 18)

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Summary of SLC22A18

The gene codes for a protein, solute carrier family 22 member 18. Mutations may cause Wilms' tumor and lung cancer [R].

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The Function of SLC22A18

May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney.

Protein names

Recommended name:

Solute carrier family 22 member 18

Short name:

ORCTL-2

Alternative name(s):

Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein
Efflux transporter-like protein
Imprinted multi-membrane-spanning polyspecific transporter-related protein 1
Organic cation transporter-like protein 2
Solute carrier family 22 member 1-like
Tumor-suppressing STF cDNA 5 protein
Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein
p45-Beckwith-Wiedemann region 1 A
p45-BWR1A

SLC22A18 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1048047 (SLC22A18) ??
  2. RS16928809 (SLC22A18) ??

Top Gene-Substance Interactions

SLC22A18 Interacts with These Diseases

Disease Score

Substances That Increase SLC22A18

Substances Interaction Organism Category

Substances That Decrease SLC22A18

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Rhabdomyosarcoma 1Familial cancer of breastLung cancerFrom UniProt: Rhabdomyosarcoma, embryonal, 1 (RMSE1): A form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchymal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. [MIM:268210] Lung cancer (LNCR): A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. [MIM:211980]

     From NCBI Gene: This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer . This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Several alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2015] From UniProt: May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • FOXO4
  • FOXO1a
  • FOXO1
  • NF-E2
  • NF-E2 p45

Tissue specificity:

Expressed at high levels in adult and fetal kidney and liver, and adult colon. Expressed in fetal renal proximal tubules (at protein level). Expressed at lower levels in heart, brain and lung.

Gene Pathways:

  • Transmembrane transport of small molecules

Caution:

It is uncertain whether Met-1 or Met-17 is the initiator.

Molecular Function:

  • Drug:Proton Antiporter Activity
  • Drug Transmembrane Transporter Activity
  • Symporter Activity
  • Ubiquitin Protein Ligase Binding

Biological Processes:

  • Drug Transport
  • Excretion
  • Organic Cation Transport
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_03072| AS27_14463| AS28_03433| beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein| BWR1A| BWSCR1A| CB1_000234011| efflux transporter-like protein| GW7_00320| H920_10144| HET| I79_015902| imprinted multi-membrane spanning polyspecific transporter-related protein 1| imprinted multi-membrane-spanning polyspecific transporter-related protein 1| IMPT1| ITM| M91_06247| M959_06689| N300_06490| N301_03993| N302_13709| N303_00166| N306_09675| N307_09256| N308_12019| N309_11048| N312_02970| N320_12327| N321_05906| N325_06104| N326_10652| N327_09410| N329_01230| N330_13870| N331_03377| N332_14577| N333_12517| N334_01132| N336_09832| N339_02121| N340_07444| ORCTL2| ORCTL-2| organic cationic transporter-like 2| organic cation transporter-like protein 2| p45 Beckwith-Wiedemann region 1A| p45-BWR1A| PAL_GLEAN10011214| PANDA_008892| Slc22a1l| solute carrier family 22, member 18| solute carrier family 22 member 18-like protein| solute carrier family 22 (organic cation transporter), member 18| TREES_T100008530| TSSC5| tumor-suppressing STF cDNA 5 protein| tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein| tumor suppressing subtransferable candidate 5| Y1Q_016670| Y956_06744| Z169_01665| zinc transporter ZnT-1| ZNT-1| slc22a18

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