The Function of SLC1A4
Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence.
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Protein names
Recommended name:
Neutral amino acid transporter AShort name:
SATTAlternative name(s):
Alanine/serine/cysteine/threonine transporter 1ASCT-1
Solute carrier family 1 member 4
- RS10211524 (SLC1A4) ??
- RS2160387 (SLC1A4) ??
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Top Gene-Substance Interactions
Substances That Increase SLC1A4
| Substances | Interaction | Organism | Category |
Substances That Decrease SLC1A4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined.
Molecular Function:
- Amino Acid Transmembrane Transporter Activity
- Chloride Channel Activity
- L-Alanine Transmembrane Transporter Activity
- L-Cystine Transmembrane Transporter Activity
- L-Glutamine Transmembrane Transporter Activity
- L-Hydroxyproline Transmembrane Transporter Activity
- L-Proline Transmembrane Transporter Activity
- L-Serine Transmembrane Transporter Activity
- L-Threonine Transmembrane Transporter Activity
- Symporter Activity
Biological Processes:
- Amino Acid Transport
- Cognition
- Glutamine Transport
- Hydroxyproline Transport
- L-Alanine Transport
- L-Cystine Transport
- L-Serine Transport
- Proline Transport
- Synaptic Transmission, Glutamatergic
- Threonine Transport
- Mitophagy In Response To Mitochondrial Depolarization
Drug Bank:
- L-Alanine