• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. SLC1A1

SLC1A1 (Solute carrier family 1 member 1)

Loading...

Summary of SLC1A1

This gene encodes a  glutamate transporters that play an essential role in transporting glutamate across plasma membranes. It also transports aspartate. Mutations are associated with higher risk for schizophrenia (R). 

0 users want this gene increased, 0 users want it decreased

The Function of SLC1A1

Transports L-glutamate, L- and D-aspartate and L-cystein (PubMed:21123949). Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5.

Protein names

Recommended name:

Excitatory amino acid transporter 3

Alternative name(s):

Excitatory amino-acid carrier 1
Neuronal and epithelial glutamate transporter
Sodium-dependent glutamate/aspartate transporter 3
Solute carrier family 1 member 1

SLC1A1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12682807 (SLC1A1) ??
  2. RS2228622 (SLC1A1) ??
  3. RS301430 (SLC1A1) ??
  4. RS3087879 (SLC1A1) ??
  5. RS3780412 (SLC1A1) ??
  6. RS3780413 (SLC1A1) ??
  7. RS7856675 (SLC1A1) ??

Top Gene-Substance Interactions

SLC1A1 Interacts with These Diseases

Disease Score

Substances That Increase SLC1A1

Substances Interaction Organism Category

Substances That Decrease SLC1A1

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Schizophrenia 18From UniProt: Dicarboxylic aminoaciduria (DCBXA): An autosomal recessive disorder characterized by abnormal excretion of urinary glutamate and aspartate, resulting from the incomplete reabsorption of anionic amino acids from the glomerular filtrate in the kidney. It can be associated with mental retardation. [MIM:222730] Schizophrenia 18 (SCZD18): A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. [MIM:615232]

     From NCBI Gene: This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010] From UniProt: Transports L-glutamate, L- and D-aspartate and L-cystein (PubMed:21123949). Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium . Negatively regulated by ARL6IP5.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1

Tissue specificity:

Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers).

Gene Pathways:

  • Glutamatergic synapse
  • Neuronal System
  • Protein digestion and absorption
  • Transmembrane transport of small molecules
  • Amino acid and oligopeptide SLC transporters

Molecular Function:

  • Amino Acid Transmembrane Transporter Activity
  • Cysteine Transmembrane Transporter Activity
  • Glutamate:Sodium Symporter Activity
  • Glutamate Binding
  • High-Affinity Glutamate Transmembrane Transporter Activity
  • L-Glutamate Transmembrane Transporter Activity

Biological Processes:

  • Chemical Synaptic Transmission
  • Cysteine Transport
  • D-Aspartate Import
  • Glutamate Secretion
  • Ion Transport
  • L-Glutamate Import
  • L-Glutamate Transmembrane Transport
  • Positive Regulation Of Heart Rate
  • Protein Homooligomerization

Drug Bank:

  • L-Aspartic Acid
  • Pregabalin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_05912| Anapl_17909| AS27_01374| AS28_06171| CB1_000131003| D623_10023565| DCBXA| eaac1| EAAC2| EAAT3| EH28_24001| excitatory amino acid carrier 1| excitatory amino-acid carrier 1| excitatory amino acid carrier 2| excitatory amino acid transporter 3| glutamate transporter| glutamate transporter mEAAC2| high-affinity glutamate transporter| I79_013641| M959_12087| MDA_GLEAN10011548| MEAAC1| N300_15544| N301_04163| N302_04778| N303_10470| N305_02294| N306_05261| N307_13576| N311_00464| N320_00528| N322_09825| N324_12516| N327_09272| N328_00779| N329_08493| N330_01076| N331_02463| N334_12133| N340_00360| neuronal and epithelial glutamate transporter| PAL_GLEAN10021056| PANDA_013714| REAAC1| renal high affinity glutamate transporter EAAC1| SCZD18| SLC1A2a| sodium-dependent glutamate/aspartate transporter 3| Solute carrier family 1 A1 (brain glutamate transporter)| solute carrier family 1 , member 1| solute carrier family 1, member 1| solute carrier family 1 (neuronal/epithelial high affinity gluta| solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1| TREES_T100010000| UY3_12473| Y1Q_027495| Y956_01920| Z169_16454| slc1a1

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved