Summary of SLC19A1
The gene codes for a protein, solute carrier family 19 member 1. It transports folate and is involved in regulating intracellular concentrations of folate.
It's better to have this gene increased
most of the time.
0 users want this gene increased,
0 users want it decreased
Protein names
Recommended name:
Folate transporter 1Short name:
RFCAlternative name(s):
FOLTIntestinal folate carrier 1
IFC-1
Placental folate transporter
Reduced folate carrier protein
Solute carrier family 19 member 1
- RS1051266 (SLC19A1) ??
- RS1051298 (SLC19A1) ??
- RS1051375 (SLC19A1) ??
- RS3788200 (SLC19A1) ??
- RS3788205 (SLC19A1) ??
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Top Gene-Substance Interactions
SLC19A1 Interacts with These Diseases
| Disease | Score |
Substances That Increase SLC19A1
| Substances | Interaction | Organism | Category |
Substances That Decrease SLC19A1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Placenta, liver, and to a much smaller extent, in lung.
Gene Pathways:
Molecular Function:
- Folic Acid Binding
- Folic Acid Transporter Activity
- Methotrexate Transporter Activity
- Reduced Folate Carrier Activity
Biological Processes:
- Folic Acid Metabolic Process
- Folic Acid Transport
- Reduced Folate Transmembrane Transport
- Female Pregnancy
Drug Bank:
- Pralatrexate
- Methotrexate