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  3. SLC19A1

SLC19A1 (Solute carrier family 19 member 1)

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Summary of SLC19A1

The gene codes for a protein, solute carrier family 19 member 1. It transports folate and is involved in regulating intracellular concentrations of folate.

It's better to have this gene increased most of the time.
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Protein names

Recommended name:

Folate transporter 1

Short name:

RFC

Alternative name(s):

FOLT
Intestinal folate carrier 1
IFC-1
Placental folate transporter
Reduced folate carrier protein
Solute carrier family 19 member 1

SLC19A1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1051266 (SLC19A1) ??
  2. RS1051298 (SLC19A1) ??
  3. RS1051375 (SLC19A1) ??
  4. RS3788200 (SLC19A1) ??
  5. RS3788205 (SLC19A1) ??

Top Gene-Substance Interactions

SLC19A1 Interacts with These Diseases

Disease Score

Substances That Increase SLC19A1

Substances Interaction Organism Category

Substances That Decrease SLC19A1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • FOXO3
  • FOXO3a
  • Pax-3
  • ARP-1
  • Roaz
  • FOXO3b

Tissue specificity:

Placenta, liver, and to a much smaller extent, in lung.

Gene Pathways:

  • Metabolism
  • Disease
  • Vitamin digestion and absorption

Molecular Function:

  • Folic Acid Binding
  • Folic Acid Transporter Activity
  • Methotrexate Transporter Activity
  • Reduced Folate Carrier Activity

Biological Processes:

  • Folic Acid Metabolic Process
  • Folic Acid Transport
  • Reduced Folate Transmembrane Transport
  • Female Pregnancy

Drug Bank:

  • Pralatrexate
  • Methotrexate
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 58 kDa hydrophobic protein| AS27_04742| CB1_000507001| chmd| fj80b07| Folate carrier protein| Folate transporter 1| folt| GW7_13729| H920_10451| IFC1| IFC-1| intestinal folate carrier 1| intestinal folate carrier protein| M91_17257| M959_07283| MDA_GLEAN10015965| methotrexate carrier 1| methotrexate carrier 2| methotrexate carrier 5| methotrexate carrier 6| Methotrexate uptake protein| MTX1| N300_12389| N301_14352| N306_13467| N307_12014| N339_06378| PAL_GLEAN10002959| placental folate transporter| reduced folate carrier| reduced folate carrier 1| reduced folate carrier protein| refc| RFC| RFC1| RFC-1| solute carrier family 19 (folate transporter), member 1| solute carrier family 19 , member 1| solute carrier family 19 (sodium/hydrogen exchanger), member 1| TREES_T100005966| UY3_13583| XRFC| Y1Q_022229| Y956_10204| slc19a1

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