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  3. SLC16A1

SLC16A1 (Solute carrier family 16 member 1)

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The Function of SLC16A1

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

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Protein names

Recommended name:

Monocarboxylate transporter 1

Short name:

MCT 1

Alternative name(s):

Solute carrier family 16 member 1

SLC16A1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1049434 (SLC16A1) ??

Top Gene-Substance Interactions

Substances That Increase SLC16A1

Substances Interaction Organism Category

Substances That Decrease SLC16A1

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: congenital hyperinsulinismFrom NCBI Gene: Exercise-induced hyperinsulinemic hypoglycemiaMonocarboxylate transporter 1 deficiencyErythrocyte lactate transporter defectFrom UniProt: Monocarboxylate transporter 1 deficiency (MCT1D): A metabolic disorder characterized by recurrent ketoacidosis, a pathologic state due to ketone formation exceeding ketone utilization. The clinical consequences of ketoacidosis are vomiting, osmotic diuresis, dehydration, and Kussmaul breathing. The condition may progress to decreased consciousness and, ultimately, death. [MIM:616095] Symptomatic deficiency in lactate transport (SDLT): Deficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals. [MIM:245340] Familial hyperinsulinemic hypoglycemia 7 (HHF7): Dominantly inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic exercise or on pyruvate load. [MIM:610021]

     From NCBI Gene: The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009] From UniProt: Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

Tissue specificity:

Detected in heart and in blood lymphocytes and monocytes (at protein level). Widely expressed.

Gene Pathways:

  • Metabolism
  • Hemostasis
  • Transmembrane transport of small molecules
  • Bile salt and organic anion SLC transporters

Molecular Function:

  • Lactate Transmembrane Transporter Activity
  • Mevalonate Transmembrane Transporter Activity
  • Monocarboxylic Acid Transmembrane Transporter Activity
  • Organic Cyclic Compound Binding
  • Symporter Activity

Biological Processes:

  • Behavioral Response To Nutrient
  • Cellular Response To Organic Cyclic Compound
  • Centrosome Organization
  • Glucose Homeostasis
  • Leukocyte Migration
  • Lipid Metabolic Process
  • Mevalonate Transport
  • Monocarboxylic Acid Transport
  • Plasma Membrane Lactate Transport
  • Pyruvate Metabolic Process
  • Regulation Of Insulin Secretion
  • Response To Food

Drug Bank:

  • Aminohippurate
  • Gamma Hydroxybutyric Acid
  • Benzoic Acid
  • Foscarnet
  • Lactic Acid
  • Methotrexate
  • Nateglinide
  • Niacin
  • Pravastatin
  • Probenecid
  • Pyruvic Acid
  • Salicylic Acid
  • Valproic Acid
  • Acetic Acid
  • Ampicillin
  • Niflumic Acid
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| MCT1| mct| A306_10193| AL022710| Anapl_02059| AS27_01935| CB1_001033053| D623_10029997| EGK_01106| H920_08282| HHF7| MCT 1| MCT1D| MDA_GLEAN10024786| monocarboxylate transporter 1| monocarboxylate transporter 1-like protein| monocarboxylate transporter 2-like protein| monocarboxylic acid transporter 1| N300_10468| N301_00784| N303_11073| N305_03346| N306_10711| N307_02113| N308_09304| N310_05990| N311_06234| N312_06538| N321_07270| N324_05975| N325_01825| N326_01167| N327_07283| N332_05571| N333_13033| N335_11923| N336_02661| N339_07372| N340_06706| N341_04497| PANDA_006724| RATMCT1| RNMCT1| slc16a1b| SMCT1| solute carrier 16 (monocarboxylic acid transporter), member 1| solute carrier family 16, member 1 (monocarboxylic acid transporter 1)| solute carrier family 16, member 1 (monocarboxylic acid transporter 1) tv1| solute carrier family 16 (monocarboxylate transporter), member 1| solute carrier family 16 (monocarboxylic acid transporters), member 1| solute carrier family 16 (monocarboxylic acid transporters), member 1B| TREES_T100005376| UY3_06853| Y1Q_005370| Y956_09022| Z169_05346| slc16a1

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