The Function of SLA
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
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Protein names
Recommended name:
Src-like-adapterAlternative name(s):
Src-like-adapter protein 1SLAP-1
hSLAP
- RS2741200 (SLA) ??
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Top Gene-Substance Interactions
Substances That Increase SLA
| Substances | Interaction | Organism | Category |
Substances That Decrease SLA
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.
Induction:
By all-trans retinoic acid (ATRA). Induction is indirect and is mediated through other proteins.