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  3. SLA

SLA (Src like adaptor)

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The Function of SLA

Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.

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Protein names

Recommended name:

Src-like-adapter

Alternative name(s):

Src-like-adapter protein 1
SLAP-1
hSLAP

SLA SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2741200 (SLA) ??

Top Gene-Substance Interactions

Substances That Increase SLA

Substances Interaction Organism Category

Substances That Decrease SLA

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • IRF-1
  • IRF-2

Tissue specificity:

Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.

Induction:

By all-trans retinoic acid (ATRA). Induction is indirect and is mediated through other proteins.

Molecular Function:

  • Sh3/Sh2 Adaptor Activity
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| sla| A306_09634| AS27_05661| AS28_00513| CB1_001179022| hSLAP| M959_15241| N300_08445| N301_04755| N302_04553| N303_07816| N305_01337| N306_01968| N307_11636| N308_13729| N309_15221| N310_06562| N311_07068| N312_00989| N320_11646| N321_12895| N322_06100| N324_12697| N325_02265| N326_04060| N327_10483| N328_12676| N329_02711| N330_05608| N331_07477| N332_04791| N333_12004| N334_08873| N335_06829| N336_01505| N339_06223| N340_13921| N341_01419| SLA1| Slap| Slap1| SLAP-1| slimma| src-like-adapter| src-like-adapter-like protein| src-like-adapter protein 1| src-like adaptor| TREES_T100003232| UY3_13675| Y1Q_001259| Y956_05114| Z169_11852

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