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  3. SKAP2

SKAP2 (Src kinase associated phosphoprotein 2)

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Summary of SKAP2

The gene codes for a protein, src kinase associated phosphoprotein 2. It plays a vital role in the Src signaling pathway, and in regulating proper activation of the immune system [R].

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The Function of SKAP2

May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.

Protein names

Recommended name:

Src kinase-associated phosphoprotein 2

Short name:

SKAP-HOM

Alternative name(s):

Pyk2/RAFTK-associated protein
Retinoic acid-induced protein 70
SKAP55 homolog
SKAP-55HOM
Src family-associated phosphoprotein 2
Src kinase-associated phosphoprotein 55-related protein
Src-associated adapter protein with PH and SH3 domains

SKAP2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10486483 (SKAP2) ??
  2. RS7804356 (SKAP2) ??

Top Gene-Substance Interactions

Substances That Increase SKAP2

Substances Interaction Organism Category

Substances That Decrease SKAP2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • FOXO3
  • FOXO3a
  • Pbx1a
  • C/EBPalpha
  • NF-E2
  • NF-E2 p45
  • FOXO3b
  • p300

Tissue specificity:

Ubiquitously expressed. Present in platelets (at protein level).

Gene Pathways:

  • Cell-Cell communication

Induction:

By retinoic acid.

Molecular Function:

  • Sh3/Sh2 Adaptor Activity

Biological Processes:

  • B Cell Activation
  • Immune Response-Activating Signal Transduction
  • Negative Regulation Of Cell Proliferation
  • Protein Complex Assembly
  • Signal Transduction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| SKAP55| A306_13336| AS27_03399| CB1_000224017| Fyn-associated phosphoprotein SKAP55 homologue| H920_07041| M91_04233| M959_00244| mSKAP55R| N301_09156| N302_15358| N303_02256| N305_02614| N306_13020| N308_15913| N310_09652| N311_11966| N312_03205| N320_03975| N321_10198| N322_09605| N324_07535| N325_03336| N326_04922| N328_00805| N329_12290| N330_12191| N332_09196| N333_10942| N335_10326| N336_08118| N339_04903| N340_14480| N341_08234| PAL_GLEAN10021848| PANDA_000665| prap| Pyk2/RAFTK-associated protein| RA70| retinoic acid-induced protein 70| Saps| scap2| Scap55r| skap2-a| skap2-b| SKAP-55HOM| SKAP55-HOM| SKAP55 homolog| SKAP55 homologue| SKAP55R| skap-hom| src-associated adapter protein with PH and SH3 domains| Src-associated adaptor protein| src family associated phosphoprotein 2| src family-associated phosphoprotein 2| src kinase-associated phosphoprotein 2| src kinase-associated phosphoprotein 55-related protein| src kinase-associated phosphoprotein of 55-related protein| TREES_T100013637| UY3_01196| Y1Q_019010| Y956_04201| Z169_16304| skap2

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