Summary of SKAP2
The gene codes for a protein, src kinase associated phosphoprotein 2. It plays a vital role in the Src signaling pathway, and in regulating proper activation of the immune system [R].
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The Function of SKAP2
May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.
Protein names
Recommended name:
Src kinase-associated phosphoprotein 2Short name:
SKAP-HOMAlternative name(s):
Pyk2/RAFTK-associated proteinRetinoic acid-induced protein 70
SKAP55 homolog
SKAP-55HOM
Src family-associated phosphoprotein 2
Src kinase-associated phosphoprotein 55-related protein
Src-associated adapter protein with PH and SH3 domains
- RS10486483 (SKAP2) ??
- RS7804356 (SKAP2) ??
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Top Gene-Substance Interactions
Substances That Increase SKAP2
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Substances That Decrease SKAP2
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Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitously expressed. Present in platelets (at protein level).
Gene Pathways:
Induction:
By retinoic acid.
Molecular Function:
Biological Processes:
- B Cell Activation
- Immune Response-Activating Signal Transduction
- Negative Regulation Of Cell Proliferation
- Protein Complex Assembly
- Signal Transduction