Summary of SIN3A
The gene codes for a protein, SIN3 transcription regulator family member A. It is a transcriptional regulatory protein [R].
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The Function of SIN3A
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation.
Protein names
Recommended name:
Paired amphipathic helix protein Sin3aAlternative name(s):
Histone deacetylase complex subunit Sin3aTranscriptional corepressor Sin3a
- RS4886707 (SIN3A) ??
- RS8028182 (SIN3A) ??
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Top Gene-Substance Interactions
SIN3A Interacts with These Diseases
| Disease | Score |
Substances That Increase SIN3A
| Substances | Interaction | Organism | Category |
Substances That Decrease SIN3A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Chromatin Binding
- Protein Deacetylase Activity
- Rna Binding
- Rna Polymerase Ii Activating Transcription Factor Binding
- Rna Polymerase Ii Transcription Corepressor Activity
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Regulatory Region Sequence-Specific Dna Binding
Biological Processes:
- Activation Of Innate Immune Response
- Aging
- Cellular Lipid Metabolic Process
- Cellular Protein Localization
- Cellular Response To Dopamine
- Cellular Response To Glucose Stimulus
- Dna Replication
- Hematopoietic Progenitor Cell Differentiation
- Histone Deacetylation
- In Utero Embryonic Development
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Circadian Rhythm
- Negative Regulation Of Histone H3-K27 Acetylation
- Negative Regulation Of Protein Localization To Nucleus
- Negative Regulation Of Transcription, Dna-Templated
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Negative Regulation Of Transcription Regulatory Region Dna Binding
- Positive Regulation Of Chromatin Silencing
- Positive Regulation Of Defense Response To Virus By Host
- Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Protein Deacetylation
- Regulation Of Hormone Levels
- Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Oxidative Stress
- Response To Methylglyoxal
- Rhythmic Process
- Transcription, Dna-Templated