Summary of SIN3A
The gene codes for a protein, SIN3 transcription regulator family member A. It is a transcriptional regulatory protein [R].
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The Function of SIN3A
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation.
Protein names
Recommended name:
Paired amphipathic helix protein Sin3aAlternative name(s):
Histone deacetylase complex subunit Sin3aTranscriptional corepressor Sin3a
- RS4886707 (SIN3A) ??
- RS8028182 (SIN3A) ??
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Top Gene-Substance Interactions
SIN3A Interacts with These Diseases
| Disease | Score |
Substances That Increase SIN3A
| Substances | Interaction | Organism | Category |
Substances That Decrease SIN3A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Transcription Regulatory Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Activating Transcription Factor Binding
- Rna Polymerase Ii Transcription Corepressor Activity
- Chromatin Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Rna Binding
- Protein Deacetylase Activity
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- In Utero Embryonic Development
- Activation Of Innate Immune Response
- Positive Regulation Of Defense Response To Virus By Host
- Hematopoietic Progenitor Cell Differentiation
- Dna Replication
- Transcription, Dna-Templated
- Protein Deacetylation
- Aging
- Regulation Of Hormone Levels
- Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
- Histone Deacetylation
- Positive Regulation Of Chromatin Silencing
- Cellular Protein Localization
- Negative Regulation Of Circadian Rhythm
- Negative Regulation Of Apoptotic Process
- Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Oxidative Stress
- Cellular Lipid Metabolic Process
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Rhythmic Process
- Response To Methylglyoxal
- Cellular Response To Glucose Stimulus
- Negative Regulation Of Protein Localization To Nucleus
- Negative Regulation Of Histone H3-K27 Acetylation
- Cellular Response To Dopamine
- Negative Regulation Of Transcription Regulatory Region Dna Binding