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  3. SIK1

SIK1 (Salt inducible kinase 1)

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The Function of SIK1

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1.

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Protein names

Recommended name:

Serine/threonine-protein kinase SIK1

Short name:

SIK-1

Alternative name(s):

Salt-inducible kinase 1
Serine/threonine-protein kinase SNF1-like kinase 1
Serine/threonine-protein kinase SNF1LK

SIK1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS229353 (SIK1) ??
  2. RS8003722 (SIK1) ??

Top Gene-Substance Interactions

Substances That Increase SIK1

Substances Interaction Organism Category

Substances That Decrease SIK1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • CREB
  • deltaCREB
  • NF-kappaB1
  • c-Fos

Enzyme Regulation:

Activated by phosphorylation on Thr-182. Also activated by phosphorylation on Thr-322 in response to increases in intracellular sodium in parallel with elevations in intracellular calcium through the reversible sodium/calcium exchanger.

Molecular Function:

  • 14-3-3 Protein Binding
  • Atp Binding
  • Camp Response Element Binding Protein Binding
  • Magnesium Ion Binding
  • Protein Kinase Binding
  • Protein Serine/Threonine Kinase Activity

Biological Processes:

  • Cardiac Muscle Cell Differentiation
  • Cell Cycle
  • Cellular Response To Hormone Stimulus
  • Entrainment Of Circadian Clock By Photoperiod
  • Intracellular Signal Transduction
  • Negative Regulation Of Creb Transcription Factor Activity
  • Negative Regulation Of Gluconeogenesis
  • Negative Regulation Of Triglyceride Biosynthetic Process
  • Positive Regulation Of Anoikis
  • Protein Autophosphorylation
  • Protein Phosphorylation
  • Regulation Of Cell Differentiation
  • Regulation Of Mitotic Cell Cycle
  • Regulation Of Myotube Differentiation
  • Regulation Of Sodium Ion Transport
  • Rhythmic Process

Drug Bank:

  • Dabrafenib
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| serine/threonine protein kinase| AS27_04911| AS28_02985| CB1_000197028| EIEE30| fj78h07| HRT-20| I79_020187| M959_08529| MDA_GLEAN10003350| msk| myocardial SNF1-like kinase| N300_12095| N301_07377| N303_14974| N305_07652| N306_09196| N307_05564| N308_06037| PAL_GLEAN10008343| Probable serine/threonine protein kinase SNF1LK (HRT-20) (Myocardial SNF1-like kinase)| protein kinase KID2| qin-induced kinase| salt-inducible kinase 1| salt-inducible kinase 2| salt-inducible protein kinase 1| salt-inducible protein kinase 2| Serine/threonine-protein kinase SIK1| serine/threonine-protein kinase SIK1-like| Serine/threonine-protein kinase SIK2| serine/threonine-protein kinase SNF1-like kinase 1| serine/threonine-protein kinase SNF1-like kinase 2| serine/threonine-protein kinase SNF1LK| SIK| SIK-1| SIK2| SIK-2| SNF1-like kinase| Snf1lk| TREES_T100005959| Y1Q_006898| Y956_10268| Z169_11041| sik1

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