The Function of SHROOM2
May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution.
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Protein names
Recommended name:
Protein Shroom2Alternative name(s):
Apical-like proteinProtein APXL
- RS2405942 (SHROOM2) ??
- RS5934683 (SHROOM2) ??
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Top Gene-Substance Interactions
Substances That Increase SHROOM2
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Substances That Decrease SHROOM2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Abundant in retina and melanoma; also in brain, placenta, lung, kidney and pancreas.
Molecular Function:
Biological Processes:
- Apical Protein Localization
- Brain Development
- Camera-Type Eye Development
- Camera-Type Eye Morphogenesis
- Cellular Pigment Accumulation
- Ear Development
- Establishment Of Melanosome Localization
- Eye Pigment Granule Organization
- Lens Morphogenesis In Camera-Type Eye
- Melanosome Organization