The Function of SHMT2
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism. Thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (PubMed:21876188). Interconversion of serine and glycine (PubMed:25619277). Associates with mitochondrial DNA (PubMed:18063578). Plays a role in the deubiquitination of target proteins as component of the BRISC complex (PubMed:24075985). Required for IFNAR1 deubiquitination by the BRISC complex (PubMed:24075985).
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Protein names
Recommended name:
Serine hydroxymethyltransferase, mitochondrialShort name:
SHMTAlternative name(s):
Glycine hydroxymethyltransferaseSerine methylase
- RS12826178 (SHMT2) ??
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Top Gene-Substance Interactions
Substances That Increase SHMT2
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Substances That Decrease SHMT2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Chromatin Binding
- Glycine Hydroxymethyltransferase Activity
- L-Allo-Threonine Aldolase Activity
- Amino Acid Binding
- Pyridoxal Phosphate Binding
Biological Processes:
- Glycine Metabolic Process
- L-Serine Metabolic Process
- L-Serine Biosynthetic Process
- One-Carbon Metabolic Process
- Positive Regulation Of Cell Proliferation
- Glycine Biosynthetic Process From Serine
- Response To Type I Interferon
- Tetrahydrofolate Interconversion
- Tetrahydrofolate Metabolic Process
- Folic Acid Metabolic Process
- Protein Tetramerization
- Protein Homotetramerization
- Protein K63-Linked Deubiquitination