• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. SHMT2

SHMT2 (Serine hydroxymethyltransferase 2)

Loading...

The Function of SHMT2

Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism. Thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (PubMed:21876188). Interconversion of serine and glycine (PubMed:25619277). Associates with mitochondrial DNA (PubMed:18063578). Plays a role in the deubiquitination of target proteins as component of the BRISC complex (PubMed:24075985). Required for IFNAR1 deubiquitination by the BRISC complex (PubMed:24075985).

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Serine hydroxymethyltransferase, mitochondrial

Short name:

SHMT

Alternative name(s):

Glycine hydroxymethyltransferase
Serine methylase

SHMT2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12826178 (SHMT2) ??

Top Gene-Substance Interactions

Substances That Increase SHMT2

Substances Interaction Organism Category

Substances That Decrease SHMT2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • c-Myc
  • GATA-1

Gene Pathways:

  • Metabolic pathways
  • One carbon pool by folate
  • Glycine, serine and threonine metabolism
  • Cyanoamino acid metabolism

Molecular Function:

  • Amino Acid Binding
  • Chromatin Binding
  • Glycine Hydroxymethyltransferase Activity
  • L-Allo-Threonine Aldolase Activity
  • Pyridoxal Phosphate Binding

Biological Processes:

  • Folic Acid Metabolic Process
  • Glycine Biosynthetic Process From Serine
  • Glycine Metabolic Process
  • L-Serine Biosynthetic Process
  • L-Serine Metabolic Process
  • One-Carbon Metabolic Process
  • Positive Regulation Of Cell Proliferation
  • Protein Homotetramerization
  • Protein K63-Linked Deubiquitination
  • Protein Tetramerization
  • Response To Type I Interferon
  • Tetrahydrofolate Interconversion
  • Tetrahydrofolate Metabolic Process

Drug Bank:

  • Tetrahydrofolic Acid
  • Glycine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| glycine hydroxymethyltransferase| serine hydroxymethyltransferase 2 (mitochondrial)| serine methylase| SHMT| A306_15444| Anapl_14522| AS27_09768| AS28_12400| CB1_000607001| EGK_03829| epididymis secretory sperm binding protein Li 51e| GLYA| GLY A+| glycine auxotroph A, human complement for hamster| GLYM| H920_14029| HEL-S-51e| M959_12152| MDA_GLEAN10006663| mitochondrial serine hydroxymethyltransferase| mitochondrial serine hydroxymethyltransferase precursor-like protein| N300_00700| N301_16115| N302_04740| N303_09846| N306_01791| N307_14153| N308_15037| N312_05927| N333_04079| N335_10412| N340_09467| PAL_GLEAN10004853| PANDA_004114| serine aldolase| serine hydroxymethylase| serine hydroxymethyltransferase, mitochondrial| serine hydroxymethyltransferase, mitochondrial-like protein| threonine aldolase| TREES_T100018339| Y956_13687| shmt2

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved