The Function of SHMT2
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism. Thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (PubMed:21876188). Interconversion of serine and glycine (PubMed:25619277). Associates with mitochondrial DNA (PubMed:18063578). Plays a role in the deubiquitination of target proteins as component of the BRISC complex (PubMed:24075985). Required for IFNAR1 deubiquitination by the BRISC complex (PubMed:24075985).
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Protein names
Recommended name:
Serine hydroxymethyltransferase, mitochondrialShort name:
SHMTAlternative name(s):
Glycine hydroxymethyltransferaseSerine methylase
- RS12826178 (SHMT2) ??
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Top Gene-Substance Interactions
Substances That Increase SHMT2
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Substances That Decrease SHMT2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Amino Acid Binding
- Chromatin Binding
- Glycine Hydroxymethyltransferase Activity
- L-Allo-Threonine Aldolase Activity
- Pyridoxal Phosphate Binding
Biological Processes:
- Folic Acid Metabolic Process
- Glycine Biosynthetic Process From Serine
- Glycine Metabolic Process
- L-Serine Biosynthetic Process
- L-Serine Metabolic Process
- One-Carbon Metabolic Process
- Positive Regulation Of Cell Proliferation
- Protein Homotetramerization
- Protein K63-Linked Deubiquitination
- Protein Tetramerization
- Response To Type I Interferon
- Tetrahydrofolate Interconversion
- Tetrahydrofolate Metabolic Process