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  3. SHMT1

SHMT1 (Serine hydroxymethyltransferase 1)

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The Function of SHMT1

Interconversion of serine and glycine (PubMed:8505317, PubMed:24698160).

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Protein names

Recommended name:

Serine hydroxymethyltransferase, cytosolic

Short name:

SHMT

Alternative name(s):

Glycine hydroxymethyltransferase
Serine methylase

SHMT1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1979277 (SHMT1) ??

Top Gene-Substance Interactions

SHMT1 Interacts with These Diseases

Disease Score

Substances That Increase SHMT1

Substances Interaction Organism Category

Substances That Decrease SHMT1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • C/EBPalpha
  • ARP-1
  • E2F-4
  • E2F-5

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Disease
  • One carbon pool by folate
  • Glycine, serine and threonine metabolism
  • Cyanoamino acid metabolism

Enzyme Regulation:

Inhibited by tetrahydrofolate concentrations above 40 uM.

Molecular Function:

  • Amino Acid Binding
  • Glycine Hydroxymethyltransferase Activity
  • L-Allo-Threonine Aldolase Activity
  • Protein Homodimerization Activity
  • Pyridoxal Phosphate Binding
  • Serine Binding

Biological Processes:

  • Carnitine Biosynthetic Process
  • Cellular Response To Tetrahydrofolate
  • Dtmp Biosynthetic Process
  • Folic Acid Metabolic Process
  • Glycine Biosynthetic Process From Serine
  • Glycine Metabolic Process
  • L-Serine Catabolic Process
  • L-Serine Metabolic Process
  • Protein Homotetramerization
  • Protein Tetramerization
  • Purine Nucleobase Biosynthetic Process
  • Tetrahydrofolate Interconversion
  • Tetrahydrofolate Metabolic Process

Drug Bank:

  • Mimosine
  • Tetrahydrofolic Acid
  • Glycine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_12316| AS28_11245| broad-complex core protein isoforms 1/2/3/4/5| C81125| CB1_000221012| CSHMT| cytoplasmic serine hydroxymethyltransferase| cytosolic serine hydroxymethyltransferase| glycine hydroxymethyltransferase| GW7_07664| H920_10934| I79_001722| LRRGT00032| M959_09469| MEL-32| mshmt| mshmt1| mshmt2| N301_06710| N302_11789| N303_05131| N305_14906| N306_14339| N307_07674| N309_09618| N310_10184| N311_06474| N321_06474| N322_07546| N324_00861| N325_03972| N326_04382| N330_05023| N332_09872| N333_06800| N335_11849| N340_06641| PAL_GLEAN10008616| PANDA_012262| serine hydroxymethyl transferase| serine hydroxymethyltransferase 1 (soluble)| serine hydroxymethyltransferase 2 (mitochondrial)| serine hydroxymethyltransferase, cytosolic| serine hydroxymethyltransferase, cytosolic-like protein| serine methylase| SHMT| SHMT2| TREES_T100005657| UY3_07304| Y1Q_008049| Z169_10225| zSHMT-1| shmt1

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