The Function of SHMT1
Interconversion of serine and glycine (PubMed:8505317, PubMed:24698160).
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Protein names
Recommended name:
Serine hydroxymethyltransferase, cytosolicShort name:
SHMTAlternative name(s):
Glycine hydroxymethyltransferaseSerine methylase
- RS1979277 (SHMT1) ??
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Top Gene-Substance Interactions
SHMT1 Interacts with These Diseases
| Disease | Score |
Substances That Increase SHMT1
| Substances | Interaction | Organism | Category |
Substances That Decrease SHMT1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Enzyme Regulation:
Inhibited by tetrahydrofolate concentrations above 40 uM.
Molecular Function:
- Amino Acid Binding
- Glycine Hydroxymethyltransferase Activity
- L-Allo-Threonine Aldolase Activity
- Protein Homodimerization Activity
- Pyridoxal Phosphate Binding
- Serine Binding
Biological Processes:
- Carnitine Biosynthetic Process
- Cellular Response To Tetrahydrofolate
- Dtmp Biosynthetic Process
- Folic Acid Metabolic Process
- Glycine Biosynthetic Process From Serine
- Glycine Metabolic Process
- L-Serine Catabolic Process
- L-Serine Metabolic Process
- Protein Homotetramerization
- Protein Tetramerization
- Purine Nucleobase Biosynthetic Process
- Tetrahydrofolate Interconversion
- Tetrahydrofolate Metabolic Process