Summary of SHMT1
The SHMT1 gene codes for an enzyme called serine hydroxymethyltransferase 1 (SHMT1) [R].
SHMT1 is important for making amino acids (protein building blocks) and purines. That makes this enzyme essential for building proteins [R].
Variants in SHMT1 have been linked to [R, R, R, R]:
- Non-Hodgkin lymphoma
- Multiple sclerosis
- Childhood acute lymphoblastic leukemia
- Essential hypertension (high blood pressure)
0 users want this gene increased,
0 users want it decreased
Protein names
Recommended name:
Serine hydroxymethyltransferase, cytosolicShort name:
SHMTAlternative name(s):
Glycine hydroxymethyltransferaseSerine methylase
- RS1979277 (SHMT1) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
SHMT1 Interacts with These Diseases
| Disease | Score |
Substances That Increase SHMT1
| Substances | Interaction | Organism | Category |
Substances That Decrease SHMT1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Enzyme Regulation:
Inhibited by tetrahydrofolate concentrations above 40 uM.
Molecular Function:
- Glycine Hydroxymethyltransferase Activity
- L-Allo-Threonine Aldolase Activity
- Amino Acid Binding
- Pyridoxal Phosphate Binding
- Protein Homodimerization Activity
- Serine Binding
Biological Processes:
- Dtmp Biosynthetic Process
- Glycine Metabolic Process
- L-Serine Metabolic Process
- L-Serine Catabolic Process
- Purine Nucleobase Biosynthetic Process
- Glycine Biosynthetic Process From Serine
- Tetrahydrofolate Interconversion
- Carnitine Biosynthetic Process
- Tetrahydrofolate Metabolic Process
- Folic Acid Metabolic Process
- Protein Tetramerization
- Protein Homotetramerization
- Cellular Response To Tetrahydrofolate