The Function of SHH
Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO.
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Protein names
Recommended name:
Sonic hedgehog proteinShort name:
SHHAlternative name(s):
HHG-1- RS34044649 (SHH) ??
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Top Gene-Substance Interactions
SHH Interacts with These Diseases
| Disease | Score |
Substances That Increase SHH
| Substances | Interaction | Organism | Category |
Substances That Decrease SHH
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in fetal intestine, liver, lung, and kidney. Not expressed in adult tissues.
Gene Pathways:
Molecular Function:
- Glycoprotein Binding
- Patched Binding
- Calcium Ion Binding
- Glycosaminoglycan Binding
- Peptidase Activity
- Zinc Ion Binding
- Morphogen Activity
- Laminin-1 Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Branching Involved In Blood Vessel Morphogenesis
- Vasculogenesis
- Metanephros Development
- Branching Involved In Ureteric Bud Morphogenesis
- Cell Fate Specification
- Neural Crest Cell Migration
- Heart Looping
- Positive Regulation Of Neuroblast Proliferation
- Osteoblast Development
- Lymphoid Progenitor Cell Differentiation
- Determination Of Left/Right Asymmetry In Lateral Mesoderm
- Endocytosis
- Smoothened Signaling Pathway
- Positive Regulation Of Hh Target Transcription Factor Activity
- Cell-Cell Signaling
- Pattern Specification Process
- Ectoderm Development
- Neuroblast Proliferation
- Axon Guidance
- Central Nervous System Development
- Ventral Midline Development
- Hindgut Morphogenesis
- Heart Development
- Blood Coagulation
- Androgen Metabolic Process
- Positive Regulation Of Cell Proliferation
- Embryo Development
- Embryonic Pattern Specification
- Polarity Specification Of Anterior/Posterior Axis
- Dorsal/Ventral Pattern Formation
- Oligodendrocyte Development
- Striated Muscle Tissue Development
- Positive Regulation Of Skeletal Muscle Cell Proliferation
- Myotube Differentiation
- Intein-Mediated Protein Splicing
- Spinal Cord Dorsal/Ventral Patterning
- Spinal Cord Motor Neuron Differentiation
- Thalamus Development
- Dorsal/Ventral Neural Tube Patterning
- Cerebellar Granule Cell Precursor Proliferation
- Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation
- Telencephalon Regionalization
- Establishment Of Cell Polarity
- Regulation Of Proteolysis
- Positive Regulation Of Wnt Signaling Pathway
- Lung Development
- Embryonic Limb Morphogenesis
- Negative Regulation Of Cell Migration
- Male Genitalia Development
- Prostate Gland Development
- Thyroid Gland Development
- Forebrain Development
- Midbrain Development
- Hindbrain Development
- Pancreas Development
- Hair Follicle Morphogenesis
- Negative Regulation Of Proteasomal Ubiquitin-Dependent Protein Catabolic Process
- T Cell Differentiation In Thymus
- Positive Regulation Of T Cell Differentiation In Thymus
- Positive Regulation Of Immature T Cell Proliferation In Thymus
- Negative Regulation Of Transcription Elongation From Rna Polymerase Ii Promoter
- Protein Localization To Nucleus
- Embryonic Forelimb Morphogenesis
- Embryonic Hindlimb Morphogenesis
- Regulation Of Cell Proliferation
- Negative Regulation Of T Cell Proliferation
- Positive Regulation Of Protein Import Into Nucleus
- Odontogenesis Of Dentin-Containing Tooth
- Regulation Of Odontogenesis
- Embryonic Digit Morphogenesis
- Camera-Type Eye Development
- Negative Regulation Of Apoptotic Process
- Cd4-Positive Or Cd8-Positive, Alpha-Beta T Cell Lineage Commitment
- Positive Thymic T Cell Selection
- Negative Thymic T Cell Selection
- Intermediate Filament Organization
- Myoblast Differentiation
- Negative Regulation Of Cell Differentiation
- Positive Regulation Of Smoothened Signaling Pathway
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Alpha-Beta T Cell Differentiation
- Negative Regulation Of Alpha-Beta T Cell Differentiation
- Cell Development
- Thymus Development
- Embryonic Digestive Tract Morphogenesis
- Embryonic Foregut Morphogenesis
- Positive Regulation Of Skeletal Muscle Tissue Development
- Animal Organ Formation
- Neuron Fate Commitment
- Embryonic Skeletal System Development
- Positive Regulation Of Oligodendrocyte Differentiation
- Branching Morphogenesis Of An Epithelial Tube
- Inner Ear Development
- Formation Of Anatomical Boundary
- Stem Cell Development
- Positive Regulation Of Striated Muscle Cell Differentiation
- Positive Regulation Of Cell Division
- Bergmann Glial Cell Differentiation
- Palate Development
- Canonical Wnt Signaling Pathway
- Limb Bud Formation
- Lung Epithelium Development
- Trachea Morphogenesis
- Branching Involved In Salivary Gland Morphogenesis
- Bud Outgrowth Involved In Lung Branching
- Right Lung Development
- Left Lung Development
- Lung Lobe Morphogenesis
- Lung-Associated Mesenchyme Development
- Primary Prostatic Bud Elongation
- Prostate Epithelial Cord Elongation
- Salivary Gland Cavitation
- Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis
- Regulation Of Prostatic Bud Formation
- Epithelial-Mesenchymal Signaling Involved In Prostate Gland Development
- Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
- Regulation Of Mesenchymal Cell Proliferation Involved In Prostate Gland Development
- Mesenchymal Smoothened Signaling Pathway Involved In Prostate Gland Development
- Artery Development
- Mesenchymal Cell Proliferation Involved In Lung Development
- Somite Development
- Positive Regulation Of Sclerotome Development
- Cellular Response To Lithium Ion
- Dopaminergic Neuron Differentiation
- Renal System Development
- Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development
- Negative Regulation Of Canonical Wnt Signaling Pathway
- Negative Regulation Of Cholesterol Efflux
- Apoptotic Signaling Pathway
- Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/Right Asymmetry
- Regulation Of Protein Localization To Nucleus
- Negative Regulation Of Dopaminergic Neuron Differentiation
- Negative Regulation Of Ureter Smooth Muscle Cell Differentiation
- Positive Regulation Of Ureter Smooth Muscle Cell Differentiation
- Negative Regulation Of Kidney Smooth Muscle Cell Differentiation
- Positive Regulation Of Kidney Smooth Muscle Cell Differentiation
- Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development
- Negative Regulation Of Mesenchymal Cell Apoptotic Process