The Function of SHC3
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
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Protein names
Recommended name:
SHC-transforming protein 3Alternative name(s):
Neuronal ShcN-Shc
Protein Rai
SHC-transforming protein C
Src homology 2 domain-containing-transforming protein C3
SH2 domain protein C3
Top Gene-Substance Interactions
Substances That Increase SHC3
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Substances That Decrease SHC3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.
Molecular Function:
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Receptor Tyrosine Kinase Binding
- Signal Transducer Activity
Biological Processes:
- Central Nervous System Development
- Epidermal Growth Factor Receptor Signaling Pathway
- Learning Or Memory
- Mapk Cascade
- Ras Protein Signal Transduction
- Synaptic Transmission, Glutamatergic
- Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway