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  3. SHANK2

SHANK2 (SH3 and multiple ankyrin repeat domains 2)

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The Function of SHANK2

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.

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Protein names

Recommended name:

SH3 and multiple ankyrin repeat domains protein 2

Alternative name(s):

Shank2
Cortactin-binding protein 1
CortBP1
Proline-rich synapse-associated protein 1

SHANK2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12281359 (SHANK2) ??
  2. RS3017493 (SHANK2) ??
  3. RS35198051 (SHANK2) ??
  4. RS525304 (SHANK2) ??

Top Gene-Substance Interactions

SHANK2 Interacts with These Diseases

Disease Score

Substances That Increase SHANK2

Substances Interaction Organism Category

Substances That Decrease SHANK2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

Tissue specificity:

Isoform 3 is present in epithelial colonic cells (at protein level).

Gene Pathways:

  • Glutamatergic synapse

Molecular Function:

  • Gkap/Homer Scaffold Activity
  • Ionotropic Glutamate Receptor Binding

Biological Processes:

  • Adult Behavior
  • Learning
  • Long Term Synaptic Depression
  • Long-Term Synaptic Potentiation
  • Social Behavior
  • Synapse Assembly
  • Vocalization Behavior
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| GKAP/SAPAP-interacting protein| SH3 and multiple ankyrin repeat domains protein 1| AS27_06618| AS28_03728| auts17| CB1_000164004| cortactin-binding protein 1| cortactin SH3 domain-binding protein| CORTBP1| cttnbp1| D623_10008415| GKAP/SAPAP interacting protein| H920_10155| I79_012960| MDA_GLEAN10003770| N300_02430| N301_01158| N302_08651| N303_04041| N305_09615| N306_09408| N307_15015| N308_05644| N311_00886| N312_11787| N320_11352| N321_01897| N322_12600| N325_08181| N326_00851| N327_02726| N328_09059| N329_12914| N330_11965| N331_12778| N333_02383| N334_03321| N336_11161| N339_01795| N340_10145| N341_05940| PAL_GLEAN10011225| PANDA_011212| proline-rich synapse associated protein 1| proline-rich synapse-associated protein 1| ProSAP1| SH3 and multiple ankyrin repeat domains 3| SH3 and multiple ankyrin repeat domains protein 2| SH3 and multiple ankyrin repeat domains protein 3| SH3 and multiple ankyrin repeat domains protein 3-like protein| SH3/ankyrin domain gene 2| SHANK| SHANK3| SPANK-3| TREES_T100012712| UY3_14806| Y1Q_000480| Y956_04487| shank2

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