The Function of SHANK2
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
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Protein names
Recommended name:
SH3 and multiple ankyrin repeat domains protein 2Alternative name(s):
Shank2Cortactin-binding protein 1
CortBP1
Proline-rich synapse-associated protein 1
- RS12281359 (SHANK2) ??
- RS3017493 (SHANK2) ??
- RS35198051 (SHANK2) ??
- RS525304 (SHANK2) ??
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Top Gene-Substance Interactions
SHANK2 Interacts with These Diseases
| Disease | Score |
Substances That Increase SHANK2
| Substances | Interaction | Organism | Category |
Substances That Decrease SHANK2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 3 is present in epithelial colonic cells (at protein level).
Gene Pathways:
Molecular Function:
Biological Processes:
- Synapse Assembly
- Learning
- Adult Behavior
- Social Behavior
- Long-Term Synaptic Potentiation
- Long Term Synaptic Depression
- Vocalization Behavior