The Function of SH3BP4
May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.
Protein names
Recommended name:
SH3 domain-binding protein 4Alternative name(s):
EH-binding protein 10Transferrin receptor-trafficking protein
- RS10174126 (SH3BP4) ??
- RS11676855 (SH3BP4) ??
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Top Gene-Substance Interactions
Substances That Increase SH3BP4
| Substances | Interaction | Organism | Category |
Substances That Decrease SH3BP4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level).
Molecular Function:
Biological Processes:
- Cellular Response To Amino Acid Stimulus
- Endocytosis
- Negative Regulation Of Cell Growth
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Gtpase Activity
- Negative Regulation Of Tor Signaling
- Positive Regulation Of Autophagy
- Protein Localization To Lysosome
- Regulation Of Catalytic Activity