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  3. SH3BP4

SH3BP4 (SH3 domain binding protein 4)

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The Function of SH3BP4

May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.

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Protein names

Recommended name:

SH3 domain-binding protein 4

Alternative name(s):

EH-binding protein 10
Transferrin receptor-trafficking protein

SH3BP4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10174126 (SH3BP4) ??
  2. RS11676855 (SH3BP4) ??

Top Gene-Substance Interactions

Substances That Increase SH3BP4

Substances Interaction Organism Category

Substances That Decrease SH3BP4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1
  • Nkx2-5
  • C/EBPbeta
  • FOXF2
  • Brachyury
  • E4BP4
  • MIF-1
  • RelA
  • Sox5

Tissue specificity:

Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level).

Molecular Function:

  • Gdp-Dissociation Inhibitor Activity
  • Ras Gtpase Binding
  • Identical Protein Binding

Biological Processes:

  • Cellular Response To Amino Acid Stimulus
  • Endocytosis
  • Negative Regulation Of Cell Growth
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Gtpase Activity
  • Negative Regulation Of Tor Signaling
  • Positive Regulation Of Autophagy
  • Protein Localization To Lysosome
  • Regulation Of Catalytic Activity
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_10593| AS28_12884| BOG25| CB1_001451007| EH-binding protein 10| H920_06148| M959_12314| MDA_GLEAN10026098| N300_02843| N301_05795| N302_14960| N303_05944| N305_06205| N306_03679| N307_09509| N308_13917| N309_11002| N310_01730| N311_02939| N312_00339| N320_03557| N321_12352| N322_07130| N324_03405| N326_05643| N327_01660| N328_11970| N330_05013| N331_09003| N332_13923| N333_10862| N334_03853| N335_00388| N339_02901| N340_13636| N341_05486| PAL_GLEAN10006388| sh3bp4a| sh3bp4-a| sh3bp4-b| SH3 domain-binding protein 4| SH3-domain binding protein 4| SH3 domain-binding protein 4-A| SH3 domain-binding protein 4-like protein| transferrin receptor-trafficking protein| TREES_T100009657| TTP| Y1Q_007421| Y956_15104| Z169_14971| sh3bp4

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