Summary of SFTPD
The gene codes for a protein, surfactant protein D. It is part of the innate immune response [R].
The Function of SFTPD
Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
Protein names
Recommended name:
Pulmonary surfactant-associated protein DShort name:
SP-DAlternative name(s):
PSP-DCollectin-7
Lung surfactant protein D
- RS1051246 (SFTPD) ??
- RS1923539 (SFTPD) ??
- RS2243639 (SFTPD) ??
- RS3923564 (SFTPD) ??
- RS7078012 (SFTPD) ??
- RS721917 (SFTPD) ??
- RS726288 (SFTPD) ??
- RS911887 (SFTPD) ??
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Top Gene-Substance Interactions
SFTPD Interacts with These Diseases
| Disease | Score |
Substances That Increase SFTPD
| Substances | Interaction | Organism | Category |
Substances That Decrease SFTPD
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in lung, brain, pancreas and adipose tissue (mainly mature adipocytes).
Gene Pathways:
Molecular Function:
Biological Processes:
- Regulation Of Cytokine Production
- Receptor-Mediated Endocytosis
- Respiratory Gaseous Exchange
- Negative Regulation Of T Cell Proliferation
- Defense Response To Bacterium
- Surfactant Homeostasis
- Cellular Protein Metabolic Process
- Negative Regulation Of Interleukin-2 Biosynthetic Process
- Innate Immune Response
- Macrophage Chemotaxis
- Lung Alveolus Development
- Positive Regulation Of Phagocytosis
- Regulation Of Immune Response
- Reactive Oxygen Species Metabolic Process