The Function of SFRP5
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.
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Protein names
Recommended name:
Secreted frizzled-related protein 5Alternative name(s):
sFRP-5Frizzled-related protein 1b
FRP-1b
Secreted apoptosis-related protein 3
SARP-3
- RS11816631 (SFRP5) ??
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Top Gene-Substance Interactions
Substances That Increase SFRP5
| Substances | Interaction | Organism | Category |
Substances That Decrease SFRP5
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle.
Gene Pathways:
Molecular Function:
Biological Processes:
- Anatomical Structure Morphogenesis
- Apoptotic Process
- Cell Differentiation
- Establishment Or Maintenance Of Cell Polarity
- Multicellular Organism Development
- Negative Regulation Of Canonical Wnt Signaling Pathway
- Negative Regulation Of Catenin Import Into Nucleus
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Protein Kinase B Signaling
- Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Negative Regulation Of Wnt Signaling Pathway
- Negative Regulation Of Wnt Signaling Pathway Involved In Digestive Tract Morphogenesis
- Non-Canonical Wnt Signaling Pathway
- Signal Transduction
- Visual Perception