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  3. SFRP5

SFRP5 (Secreted frizzled related protein 5)

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The Function of SFRP5

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.

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Protein names

Recommended name:

Secreted frizzled-related protein 5

Alternative name(s):

sFRP-5
Frizzled-related protein 1b
FRP-1b
Secreted apoptosis-related protein 3
SARP-3

SFRP5 SNPs

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  1. RS11816631 (SFRP5) ??

Top Gene-Substance Interactions

Substances That Increase SFRP5

Substances Interaction Organism Category

Substances That Decrease SFRP5

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • Pbx1a
  • HNF-4alpha1
  • HNF-4alpha2
  • GATA-1
  • E4BP4
  • GATA-2
  • GATA-3

Tissue specificity:

Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle.

Gene Pathways:

  • Wnt signaling pathway

Molecular Function:

  • G-Protein Coupled Receptor Activity
  • Wnt-Activated Receptor Activity
  • Wnt-Protein Binding

Biological Processes:

  • Anatomical Structure Morphogenesis
  • Apoptotic Process
  • Cell Differentiation
  • Establishment Or Maintenance Of Cell Polarity
  • Multicellular Organism Development
  • Negative Regulation Of Canonical Wnt Signaling Pathway
  • Negative Regulation Of Catenin Import Into Nucleus
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Protein Kinase B Signaling
  • Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
  • Negative Regulation Of Wnt Signaling Pathway
  • Negative Regulation Of Wnt Signaling Pathway Involved In Digestive Tract Morphogenesis
  • Non-Canonical Wnt Signaling Pathway
  • Signal Transduction
  • Visual Perception
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| sfrp1| secreted frizzled-related sequence protein 5| A306_06145| AS27_02668| CB1_000770016| D144| EH28_11328| frizzled-related protein 1b| frp1| FRP-1b| frp5| H920_11411| I79_003428| M91_14357| M959_09946| MDA_GLEAN10023430| N301_11555| N302_13551| N309_15414| N310_12321| N330_07818| PAL_GLEAN10018300| PANDA_005181| SARP3| SARP-3| secreted apoptosis related protein 3| secreted frizzled-related protein 5| sFRP-5| sfrp5-a| sfrp5-b| TREES_T100012265| XsFRP5| Y1Q_005358| Z169_15994| sfrp5

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