Summary of SFRP1
The gene codes for a protein, secreted frizzled related protein 1. It helps determine the polarity of photoreceptor cells in the retina [R].
The Function of SFRP1
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.
Protein names
Recommended name:
Secreted frizzled-related protein 1Short name:
FRP-1Alternative name(s):
sFRP-1Secreted apoptosis-related protein 2
SARP-2
- RS3242 (SFRP1) ??
- RS77924284 (SFRP1) ??
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Top Gene-Substance Interactions
Substances That Increase SFRP1
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Substances That Decrease SFRP1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes.
Gene Pathways:
Induction:
Down-regulated in colorectal and breast tumors. Up-regulated in uterine leiomyomas under high estrogenic conditions. Expression, in leiomyomal cells, also increased both under hypoxic and serum deprivation conditions.
Molecular Function:
- Cysteine-Type Endopeptidase Activity
- G-Protein Coupled Receptor Activity
- Frizzled Binding
- Drug Binding
- Heparin Binding
- Wnt-Protein Binding
- Identical Protein Binding
- Wnt-Activated Receptor Activity
Biological Processes:
- Osteoblast Differentiation
- Ureteric Bud Development
- Positive Regulation Of Cell-Matrix Adhesion
- Hematopoietic Progenitor Cell Differentiation
- Positive Regulation Of Cell Proliferation
- Negative Regulation Of Cell Proliferation
- Male Gonad Development
- Female Gonad Development
- Cellular Response To Starvation
- Dorsal/Ventral Axis Specification
- Regulation Of Cell Cycle Process
- Negative Regulation Of Gene Expression
- Negative Regulation Of Epithelial To Mesenchymal Transition
- Regulation Of Neuron Projection Development
- Neural Crest Cell Fate Commitment
- Response To Organic Cyclic Compound
- Menstrual Cycle Phase
- Positive Regulation Of Wnt Signaling Pathway
- Negative Regulation Of Wnt Signaling Pathway
- Negative Regulation Of Ossification
- Positive Regulation Of Cell Growth
- Negative Regulation Of Cell Growth
- Negative Regulation Of Cell Migration
- Negative Regulation Of Bmp Signaling Pathway
- Negative Regulation Of Osteoblast Proliferation
- Somatic Stem Cell Population Maintenance
- Positive Regulation Of Apoptotic Process
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Jun Kinase Activity
- Positive Regulation Of Gtpase Activity
- Cellular Response To Fibroblast Growth Factor Stimulus
- Stromal-Epithelial Cell Signaling Involved In Prostate Gland Development
- Negative Regulation Of B Cell Differentiation
- Positive Regulation Of Fat Cell Differentiation
- Negative Regulation Of Osteoblast Differentiation
- Negative Regulation Of Osteoclast Differentiation
- Regulation Of Angiogenesis
- Positive Regulation Of Smoothened Signaling Pathway
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Negative Regulation Of Insulin Secretion
- Negative Regulation Of Bone Remodeling
- Negative Regulation Of Fibroblast Proliferation
- Digestive Tract Morphogenesis
- Positive Regulation Of Epithelial Cell Proliferation
- Negative Regulation Of Epithelial Cell Proliferation
- Negative Regulation Of Peptidyl-Tyrosine Phosphorylation
- Positive Regulation Of Stress Fiber Assembly
- Positive Regulation Of Focal Adhesion Assembly
- Canonical Wnt Signaling Pathway
- Hematopoietic Stem Cell Differentiation
- Bone Trabecula Formation
- Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis
- Regulation Of Branching Involved In Prostate Gland Morphogenesis
- Negative Regulation Of Androgen Receptor Signaling Pathway
- Cellular Response To Vitamin D
- Cellular Response To Interleukin-1
- Cellular Response To Tumor Necrosis Factor
- Cellular Response To Growth Factor Stimulus
- Cellular Response To Prostaglandin E Stimulus
- Cellular Response To Estrogen Stimulus
- Cellular Response To Estradiol Stimulus
- Cellular Response To Hypoxia
- Cellular Response To X-Ray
- Cellular Response To Heparin
- Dopaminergic Neuron Differentiation
- Cellular Response To Transforming Growth Factor Beta Stimulus
- Cellular Response To Bmp Stimulus
- Negative Regulation Of Canonical Wnt Signaling Pathway
- Planar Cell Polarity Pathway Involved In Neural Tube Closure
- Wnt Signaling Pathway Involved In Somitogenesis
- Convergent Extension Involved In Somitogenesis
- Positive Regulation Of Canonical Wnt Signaling Pathway
- Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- Regulation Of Dopaminergic Neuron Differentiation
- Midbrain Morphogenesis
- Regulation Of Midbrain Dopaminergic Neuron Differentiation
- Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation
- Positive Regulation Of Non-Canonical Wnt Signaling Pathway
- Negative Regulation Of Wnt Signaling Pathway Involved In Dorsal/Ventral Axis Specification
- Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation
- Negative Regulation Of Fibroblast Apoptotic Process
- Positive Regulation Of Fibroblast Apoptotic Process