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  3. SERPINE1

SERPINE1 (Serpin family E member 1)

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Summary of SERPINE1

The gene codes for a protein, serpin family E member 1. Defects cause plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency). High concentrations are linked to thrombophilia [R].

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The Function of SERPINE1

Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.

Protein names

Recommended name:

Plasminogen activator inhibitor 1

Short name:

PAI

Alternative name(s):

PAI-1
Endothelial plasminogen activator inhibitor
Serpin E1

SERPINE1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1799768 (SERPINE1) ??
  2. RS2227631 (SERPINE1) ??
  3. RS2227667 (SERPINE1) ??
  4. RS2227684 (SERPINE1) ??
  5. RS7242 (SERPINE1) ??

Top Gene-Substance Interactions

SERPINE1 Interacts with These Diseases

Disease Score

Substances That Increase SERPINE1

Substances Interaction Organism Category

Substances That Decrease SERPINE1

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Plasminogen activator inhibitor type 1 deficiencyFrom UniProt: High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions. Plasminogen activator inhibitor-1 deficiency (PAI-1D): A hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen. [MIM:613329]

     From NCBI Gene: This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] From UniProt: Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • AP-1
  • c-Jun
  • NF-kappaB1
  • c-Fos
  • SREBP-1a
  • SREBP-1c
  • SREBP-1b

Tissue specificity:

Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells.

Gene Pathways:

  • Hemostasis
  • p53 signaling pathway
  • Chagas disease (American trypanosomiasis)
  • Complement and coagulation cascades
  • Signal Transduction
  • Gene Expression
  • Disease
  • Circadian Clock
  • Extracellular matrix organization

Molecular Function:

  • Protease Binding
  • Receptor Binding
  • Serine-Type Endopeptidase Inhibitor Activity

Biological Processes:

  • Angiogenesis
  • Cellular Response To Lipopolysaccharide
  • Chronological Cell Aging
  • Circadian Rhythm
  • Defense Response To Gram-Negative Bacterium
  • Extracellular Matrix Organization
  • Fibrinolysis
  • Negative Regulation Of Blood Coagulation
  • Negative Regulation Of Cell Adhesion Mediated By Integrin
  • Negative Regulation Of Cell Migration
  • Negative Regulation Of Endopeptidase Activity
  • Negative Regulation Of Endothelial Cell Apoptotic Process
  • Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
  • Negative Regulation Of Fibrinolysis
  • Negative Regulation Of Plasminogen Activation
  • Negative Regulation Of Smooth Muscle Cell-Matrix Adhesion
  • Negative Regulation Of Smooth Muscle Cell Migration
  • Negative Regulation Of Vascular Wound Healing
  • Negative Regulation Of Wound Healing
  • Platelet Degranulation
  • Positive Regulation Of Angiogenesis
  • Positive Regulation Of Blood Coagulation
  • Positive Regulation Of Inflammatory Response
  • Positive Regulation Of Interleukin-8 Production
  • Positive Regulation Of Leukotriene Production Involved In Inflammatory Response
  • Positive Regulation Of Monocyte Chemotaxis
  • Positive Regulation Of Receptor-Mediated Endocytosis
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Receptor Activity

Drug Bank:

  • Alteplase
  • Anistreplase
  • Drotrecogin Alfa
  • Urokinase
  • Tenecteplase
  • Reteplase
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| chemokine CCL-C25s| clade E serpine peptidase inhibitor| D623_10015191| EH28_18175| endothelial plasminogen activator inhibitor| GW7_12460| I79_007296| nexin| nexin, plasminogen activator inhibitor type 1| PAI| PAI1| PAI 1| PAI-1| PAI1A| Pai1aa| PAL_GLEAN10012062| PANDA_021149| Planh| PLANH1| plasminogen activator inhibitor| plasminogen activator inhibitor 1| plasminogen activator inhibitor-1| plasminogen activator inhibitor 1-like protein| Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI)| plasminogen activator inhibitor I| plasminogen activator inhibitor type 1| plasminogen activator inhibitor, type 1| plasminogen activator inhibitor, type I| putative plasminogen activator inhibitor-1| RATPAI1A| serine (or cysteine) peptidase inhibitor, clade E, member 1| serine (or cysteine) proteinase inhibitor, clade E, member 1| serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1| serine (or cysteine) proteinase inhibitor, member 1| serpin E1| serpin peptidase inhibitor clade E member 1| serpin peptidase inhibitor, clade E , member 1| serpin peptidase inhibitor, clade E, member 1| serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1| serpine1

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