The Function of SERPINB5
Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
0 users want this gene increased,
0 users want it decreased
Protein names
Recommended name:
Serpin B5Short name:
PI-5Alternative name(s):
MaspinPeptidase inhibitor 5
- RS2032224 (SERPINB5) ??
- RS79285331 (SERPINB5) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
SERPINB5 Interacts with These Diseases
| Disease | Score |
Substances That Increase SERPINB5
| Substances | Interaction | Organism | Category |
Substances That Decrease SERPINB5
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Normal mammary epithelial cells.
Gene Pathways:
Molecular Function:
Biological Processes:
- Morphogenesis Of An Epithelium
- Movement Of Cell Or Subcellular Component
- Extracellular Matrix Organization
- Regulation Of Epithelial Cell Proliferation
- Prostate Gland Morphogenesis