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  3. SERPINB5

SERPINB5 (Serpin family B member 5)

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The Function of SERPINB5

Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

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Protein names

Recommended name:

Serpin B5

Short name:

PI-5

Alternative name(s):

Maspin
Peptidase inhibitor 5

SERPINB5 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2032224 (SERPINB5) ??
  2. RS79285331 (SERPINB5) ??

Top Gene-Substance Interactions

SERPINB5 Interacts with These Diseases

Disease Score

Substances That Increase SERPINB5

Substances Interaction Organism Category

Substances That Decrease SERPINB5

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • Sp1
  • Nkx3-1 v1
  • Nkx3-1

Tissue specificity:

Normal mammary epithelial cells.

Gene Pathways:

  • p53 signaling pathway

Molecular Function:

  • Serine-Type Endopeptidase Inhibitor Activity

Biological Processes:

  • Extracellular Matrix Organization
  • Morphogenesis Of An Epithelium
  • Movement Of Cell Or Subcellular Component
  • Prostate Gland Morphogenesis
  • Regulation Of Epithelial Cell Proliferation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| serpin peptidase inhibitor, clade B (ovalbumin), member 5| A306_09667| AS27_14691| AS28_12482| CB1_000632077| H920_14126| M91_01993| M959_00522| Maspin| MDA_GLEAN10017753| N300_12630| N301_12943| N302_06302| N303_03434| N305_03852| N306_04132| N307_09673| N308_04424| N309_12710| N310_00829| N311_01060| N312_04002| N320_01045| N321_02932| N322_13645| N324_00385| N325_04422| N326_01092| N327_00693| N328_00871| N329_09839| N330_11241| N331_05818| N332_06305| N333_05393| N334_09507| N336_03700| N340_03228| N341_01649| ovalbumin| PAL_GLEAN10017124| peptidase inhibitor 5| Pi5| PI-5| protease inhibitor 5| protease inhibitor 5 (maspin)| serine (or cysteine) peptidase inhibitor, clade B, member 5| serine (or cysteine) proteinase inhibitor, clade B, member 5| serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5| serine protease inhibitor 7| serpin B5| serpin peptidase inhibitor, clade B , member 5| Spi7| TREES_T100000238| Y956_11926| Z169_06448| serpinb5

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