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  3. SERPINA4

SERPINA4 (Serpin family A member 4)

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The Function of SERPINA4

Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.

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Protein names

Recommended name:

Kallistatin

Short name:

PI-4

Alternative name(s):

Kallikrein inhibitor
Peptidase inhibitor 4
Serpin A4

Top Gene-Substance Interactions

Substances That Decrease SERPINA4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • HNF-1A
  • CREB
  • HNF-1
  • Bach2
  • TGIF
  • RREB-1

Tissue specificity:

Expressed by the liver and secreted in plasma.

Molecular Function:

  • Serine-Type Endopeptidase Inhibitor Activity

Biological Processes:

  • Platelet Degranulation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Alpha-1-antichymotrypsin| CB1_000726080| corticosteroid binding globulin| I79_007747| KAL| kallikrein inhibitor| Kallistatin| KLST| KST| PANDA_009261| peptidase inhibitor 4| PI4| PI-4| protease inhibitor 4 (kallistatin)| serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4| serpin A4| serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4| sserpin family A member 4| testicular secretory protein Li 22| TREES_T100005827| serpina4

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