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SERPINA3 (Serpin family A member 3)

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Summary of SERPINA3

The gene codes for a protein, serpin family A member 3. Variations are linked to Alzheimer's disease, and deficiency may cause liver disease. Mutations are associated with Parkinson disease and chronic obstructive pulmonary disease [R].

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The Function of SERPINA3

Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.

Protein names

Recommended name:

Alpha-1-antichymotrypsin

Short name:

ACT

Alternative name(s):

Cell growth-inhibiting gene 24/25 protein
Serpin A3

SERPINA3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS17473 (SERPINA3) ??
  2. RS1884082 (SERPINA3) ??
  3. RS4934 (SERPINA3) ??
  4. RS8005845 (SERPINA3) ??

Top Gene-Substance Interactions

SERPINA3 Interacts with These Diseases

Disease Score

Substances That Increase SERPINA3

Substances Interaction Organism Category

Substances That Decrease SERPINA3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • STAT3
  • STAT1
  • STAT1beta
  • STAT1alpha

Tissue specificity:

Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.

Caution:

It is uncertain whether Met-1 or Met-4 is the initiator.

Molecular Function:

  • Dna Binding
  • Serine-Type Endopeptidase Inhibitor Activity

Biological Processes:

  • Acute-Phase Response
  • Inflammatory Response
  • Maintenance Of Gastrointestinal Epithelium
  • Platelet Degranulation
  • Regulation Of Lipid Metabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ACT| serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1| serine proteinase inhibitor, clade A, member 1| serpina1| AACT| Alpha-1-antichymotrypsin| cell growth-inhibiting gene 24/25 protein| EGK_18506| GIG24| GIG25| growth-inhibiting protein 24| growth-inhibiting protein 25| H920_17263| PANDA_009263| serine (or cysteine) proteinase inhibitor, clade A, member 3| serpin A3| serpin A3-5| SERPINA3-5| serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3| serpin peptidase inhibitor, clade A, member 3| TREES_T100005829| serpina3

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