Summary of SERPINA3
The gene codes for a protein, serpin family A member 3. Variations are linked to Alzheimer's disease, and deficiency may cause liver disease. Mutations are associated with Parkinson disease and chronic obstructive pulmonary disease [R].
The Function of SERPINA3
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
Protein names
Recommended name:
Alpha-1-antichymotrypsinShort name:
ACTAlternative name(s):
Cell growth-inhibiting gene 24/25 proteinSerpin A3
- RS17473 (SERPINA3) ??
- RS1884082 (SERPINA3) ??
- RS4934 (SERPINA3) ??
- RS8005845 (SERPINA3) ??
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Top Gene-Substance Interactions
SERPINA3 Interacts with These Diseases
| Disease | Score |
Substances That Increase SERPINA3
| Substances | Interaction | Organism | Category |
Substances That Decrease SERPINA3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
Caution:
It is uncertain whether Met-1 or Met-4 is the initiator.
Molecular Function:
Biological Processes:
- Platelet Degranulation
- Acute-Phase Response
- Inflammatory Response
- Regulation Of Lipid Metabolic Process
- Maintenance Of Gastrointestinal Epithelium