Summary of SEMA5A
The gene codes for a protein, semaphorin 5A. It plays a role in axonal guidance during neural development. It may be an autism susceptibility gene [R].
The Function of SEMA5A
Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.
Protein names
Recommended name:
Semaphorin-5AAlternative name(s):
Semaphorin-FSema F
- RS11134338 (SEMA5A) ??
- RS2463505 (SEMA5A) ??
- RS433755 (SEMA5A) ??
- RS6896702 (SEMA5A) ??
- RS7702187 (SEMA5A) ??
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Top Gene-Substance Interactions
Substances That Increase SEMA5A
| Substances | Interaction | Organism | Category |
Substances That Decrease SEMA5A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Chemorepellent Activity
- Chondroitin Sulfate Proteoglycan Binding
- Heparan Sulfate Proteoglycan Binding
- Semaphorin Receptor Binding
- Syndecan Binding
Biological Processes:
- Axonal Fasciculation
- Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
- Cell Adhesion
- Cell-Cell Signaling
- Cell Chemotaxis
- Diencephalon Development
- Negative Regulation Of Axon Extension Involved In Axon Guidance
- Negative Regulation Of Cell Adhesion
- Negative Regulation Of Endothelial Cell Apoptotic Process
- Nervous System Development
- Neural Crest Cell Migration
- Positive Chemotaxis
- Positive Regulation Of Actin Filament Depolymerization
- Positive Regulation Of Angiogenesis
- Positive Regulation Of Axon Extension Involved In Axon Guidance
- Positive Regulation Of Catenin Import Into Nucleus
- Positive Regulation Of Cell Migration
- Positive Regulation Of Endothelial Cell Chemotaxis
- Positive Regulation Of Endothelial Cell Proliferation
- Positive Regulation Of Protein Kinase B Signaling
- Semaphorin-Plexin Signaling Pathway
- Signal Clustering