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  3. SEMA5A

SEMA5A (Semaphorin 5A)

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Summary of SEMA5A

The gene codes for a protein, semaphorin 5A. It plays a role in axonal guidance during neural development. It may be an autism susceptibility gene [R].

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The Function of SEMA5A

Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.

Protein names

Recommended name:

Semaphorin-5A

Alternative name(s):

Semaphorin-F
Sema F

SEMA5A SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11134338 (SEMA5A) ??
  2. RS2463505 (SEMA5A) ??
  3. RS433755 (SEMA5A) ??
  4. RS6896702 (SEMA5A) ??
  5. RS7702187 (SEMA5A) ??

Top Gene-Substance Interactions

Substances That Increase SEMA5A

Substances Interaction Organism Category

Substances That Decrease SEMA5A

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

Gene Pathways:

  • Metabolism of proteins
  • Axon guidance

Molecular Function:

  • Chemorepellent Activity
  • Chondroitin Sulfate Proteoglycan Binding
  • Heparan Sulfate Proteoglycan Binding
  • Semaphorin Receptor Binding
  • Syndecan Binding

Biological Processes:

  • Axonal Fasciculation
  • Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
  • Cell Adhesion
  • Cell-Cell Signaling
  • Cell Chemotaxis
  • Diencephalon Development
  • Negative Regulation Of Axon Extension Involved In Axon Guidance
  • Negative Regulation Of Cell Adhesion
  • Negative Regulation Of Endothelial Cell Apoptotic Process
  • Nervous System Development
  • Neural Crest Cell Migration
  • Positive Chemotaxis
  • Positive Regulation Of Actin Filament Depolymerization
  • Positive Regulation Of Angiogenesis
  • Positive Regulation Of Axon Extension Involved In Axon Guidance
  • Positive Regulation Of Catenin Import Into Nucleus
  • Positive Regulation Of Cell Migration
  • Positive Regulation Of Endothelial Cell Chemotaxis
  • Positive Regulation Of Endothelial Cell Proliferation
  • Positive Regulation Of Protein Kinase B Signaling
  • Semaphorin-Plexin Signaling Pathway
  • Signal Clustering
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 5930434A13| AS28_02654| CB1_064113032| D623_10029773| EH28_08409| GW7_17838| H920_00097| I79_006333| M959_07648| MDA_GLEAN10024081| M-Sema D| N300_02801| N301_00384| N302_06183| N303_00079| N305_08210| N306_05108| N307_14332| N308_00150| N309_04846| N310_09402| N311_02711| N312_10841| N320_09786| N321_12390| N328_11789| N330_12335| N332_14291| N333_11768| N335_13477| N336_12875| PAL_GLEAN10004731| PANDA_007165| sema domain, seven thrombospondin repeats , transmembrane domain and short cytoplasmic domain, 5A| sema domain, seven thrombospondin repeats (type 1 and type 1-lik| sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A| sema F| SEMAF| Semaphorin-5A| semaphorin F| semaphorin-F| semF| TREES_T100020303| UY3_05130| Y1Q_025848| Y956_16490| Z169_05923| sema5a

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