Summary of SEMA5A
The gene codes for a protein, semaphorin 5A. It plays a role in axonal guidance during neural development. It may be an autism susceptibility gene [R].
The Function of SEMA5A
Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.
Protein names
Recommended name:
Semaphorin-5AAlternative name(s):
Semaphorin-FSema F
- RS11134338 (SEMA5A) ??
- RS2463505 (SEMA5A) ??
- RS433755 (SEMA5A) ??
- RS6896702 (SEMA5A) ??
- RS7702187 (SEMA5A) ??
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Top Gene-Substance Interactions
Substances That Increase SEMA5A
| Substances | Interaction | Organism | Category |
Substances That Decrease SEMA5A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Semaphorin Receptor Binding
- Chondroitin Sulfate Proteoglycan Binding
- Heparan Sulfate Proteoglycan Binding
- Chemorepellent Activity
- Syndecan Binding
Biological Processes:
- Neural Crest Cell Migration
- Positive Regulation Of Endothelial Cell Proliferation
- Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
- Cell Adhesion
- Negative Regulation Of Cell Adhesion
- Cell-Cell Signaling
- Nervous System Development
- Axonal Fasciculation
- Diencephalon Development
- Positive Regulation Of Cell Migration
- Positive Regulation Of Actin Filament Depolymerization
- Positive Regulation Of Catenin Import Into Nucleus
- Positive Regulation Of Angiogenesis
- Positive Regulation Of Axon Extension Involved In Axon Guidance
- Negative Regulation Of Axon Extension Involved In Axon Guidance
- Positive Chemotaxis
- Positive Regulation Of Protein Kinase B Signaling
- Cell Chemotaxis
- Semaphorin-Plexin Signaling Pathway
- Signal Clustering
- Negative Regulation Of Endothelial Cell Apoptotic Process
- Positive Regulation Of Endothelial Cell Chemotaxis