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  3. SEMA3C

SEMA3C (Semaphorin 3C)

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The Function of SEMA3C

Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance.

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Protein names

Recommended name:

Semaphorin-3C

Alternative name(s):

Semaphorin-E
Sema E

SEMA3C SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1509911 (SEMA3C) ??
  2. RS17154917 (SEMA3C) ??
  3. RS2366858 (SEMA3C) ??
  4. RS4236644 (SEMA3C) ??
  5. RS500454 (SEMA3C) ??

Top Gene-Substance Interactions

Substances That Increase SEMA3C

Substances Interaction Organism Category

Substances That Decrease SEMA3C

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Meis-1
  • Meis-1b

Tissue specificity:

Expressed intensely in the heart, skeletal muscle, colon, small intestine, ovary, testis, and prostate. Faint expression ubiquitously among other organs, including brain.

Gene Pathways:

  • Axon guidance

Molecular Function:

  • Chemorepellent Activity
  • Neuropilin Binding
  • Semaphorin Receptor Binding

Biological Processes:

  • Axon Guidance
  • Blood Vessel Remodeling
  • Cardiac Right Ventricle Morphogenesis
  • Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching
  • Immune Response
  • Limb Bud Formation
  • Negative Chemotaxis
  • Negative Regulation Of Axon Extension Involved In Axon Guidance
  • Neural Crest Cell Migration
  • Neural Tube Development
  • Outflow Tract Morphogenesis
  • Positive Regulation Of Cell Migration
  • Post-Embryonic Development
  • Pulmonary Myocardium Development
  • Semaphorin-Plexin Signaling Pathway
  • Somitogenesis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| sema domain, immunoglobulin domain (Ig), short basic domain, sec| AS27_15270| AS28_06479| CB1_001093003| COLL-3| collapsin-3| D623_10025626| GW7_06117| H920_01045| I79_011943| M91_06784| M959_02414| N300_00464| N301_07888| N302_11978| N303_03573| N305_07536| N306_11505| N307_02398| N308_09544| N310_00961| N311_00668| N312_01717| N320_01504| N321_07061| N322_02970| N326_02654| N327_11969| N328_03282| N329_09619| N330_09940| N331_01668| N332_14027| N333_03023| N334_01567| N335_12832| N336_06246| N339_06372| N340_07717| PAL_GLEAN10013662| SEMA3F| sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C| sema domain, immunoglobulin domain , short basic domain, secreted, 3C| sema E| SEMAE| semaphorin-3C| semaphorin-3C-like protein| semaphorin E| SemE| TREES_T100021511| Y1Q_024275| Y956_10546| sema3c

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