The Function of SEMA3C
Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance.
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Protein names
Recommended name:
Semaphorin-3CAlternative name(s):
Semaphorin-ESema E
- RS1509911 (SEMA3C) ??
- RS17154917 (SEMA3C) ??
- RS2366858 (SEMA3C) ??
- RS4236644 (SEMA3C) ??
- RS500454 (SEMA3C) ??
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Top Gene-Substance Interactions
Substances That Increase SEMA3C
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Substances That Decrease SEMA3C
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed intensely in the heart, skeletal muscle, colon, small intestine, ovary, testis, and prostate. Faint expression ubiquitously among other organs, including brain.
Gene Pathways:
Molecular Function:
Biological Processes:
- Neural Crest Cell Migration
- Somitogenesis
- Blood Vessel Remodeling
- Outflow Tract Morphogenesis
- Cardiac Right Ventricle Morphogenesis
- Pulmonary Myocardium Development
- Immune Response
- Axon Guidance
- Post-Embryonic Development
- Neural Tube Development
- Positive Regulation Of Cell Migration
- Negative Regulation Of Axon Extension Involved In Axon Guidance
- Negative Chemotaxis
- Limb Bud Formation
- Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching
- Semaphorin-Plexin Signaling Pathway