Disease	Score

Substances	Interaction	Organism	Category

Substances	Interaction	Organism	Category

     From NCBI Gene: Ige responsiveness, atopicFrom UniProt: Ischemic stroke (ISCHSTR): A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. [MIM:601367]

     From NCBI Gene: This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008] From UniProt: Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

The following transcription factors affect gene expression:

• NF-kappaB
• PPAR-gamma1
• CUTL1
• PPAR-gamma2
• AP-1
• c-Jun
• NF-kappaB1
• c-Fos

Tissue specificity:

Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.

Molecular Function:

• Lipopolysaccharide Binding
• Glycoprotein Binding
• Heparin Binding
• Selenium Binding
• Sialic Acid Binding
• Fucose Binding
• Glycosphingolipid Binding
• Oligosaccharide Binding

Biological Processes:

• Selenium Compound Metabolic Process
• Platelet Degranulation
• Positive Regulation Of Leukocyte Migration
• Regulation Of Cellular Extravasation
• Inflammatory Response
• Response To Oxidative Stress
• Cell Adhesion
• Heterophilic Cell-Cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
• Leukocyte Cell-Cell Adhesion
• Brain Development
• Locomotory Behavior
• Post-Embryonic Development
• Positive Regulation Of Platelet Activation
• Positive Regulation Of Phosphatidylinositol 3-Kinase Signaling
• Response To Organic Cyclic Compound
• Sexual Reproduction
• Response To Lipopolysaccharide
• Regulation Of Integrin Activation
• Calcium-Mediated Signaling Using Intracellular Calcium Source
• Growth
• Positive Regulation Of Cell Adhesion
• Defense Response To Gram-Negative Bacterium
• Leukocyte Migration
• Leukocyte Tethering Or Rolling

Drug Bank:

• Dalteparin
• Heparin
• Nadroparin

*synonyms