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  3. SELE

SELE (Selectin E)

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Summary of SELE

This gene encodes a protein that plays an important role during inflammation. It is associated with high cholesterol (R). 

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The Function of SELE

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.

Protein names

Recommended name:

E-selectin

Short name:

ELAM-1

Alternative name(s):

CD62 antigen-like family member E
Endothelial leukocyte adhesion molecule 1
Leukocyte-endothelial cell adhesion molecule 2
LECAM2
CD antigen CD62E

SELE SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1805193 (SELE) ??
  2. RS5355 (SELE) ??
  3. RS5361 (SELE) ??
  4. RS5368 (SELE) ??

Top Gene-Substance Interactions

SELE Interacts with These Diseases

Disease Score

Substances That Increase SELE

Substances Interaction Organism Category

Substances That Decrease SELE

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Essential hypertension

     From NCBI Gene: The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008] From UniProt: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • GR
  • GR-alpha
  • GR-beta
  • CREB
  • AP-1
  • c-Jun
  • NF-kappaB1

Gene Pathways:

  • Hemostasis
  • Cell adhesion molecules (CAMs)
  • African trypanosomiasis
  • Malaria

Molecular Function:

  • Oligosaccharide Binding
  • Phospholipase Binding
  • Sialic Acid Binding
  • Transmembrane Signaling Receptor Activity

Biological Processes:

  • Actin Filament-Based Process
  • Activation Of Phospholipase C Activity
  • Calcium-Mediated Signaling
  • Heterophilic Cell-Cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
  • Inflammatory Response
  • Leukocyte Cell-Cell Adhesion
  • Leukocyte Migration
  • Leukocyte Migration Involved In Inflammatory Response
  • Leukocyte Tethering Or Rolling
  • Positive Regulation Of Receptor Internalization
  • Regulation Of Inflammatory Response
  • Response To Interleukin-1
  • Response To Lipopolysaccharide
  • Response To Tumor Necrosis Factor

Drug Bank:

  • Carvedilol
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_13625| AS27_15737| CD62 antigen-like family member E| CD62E| Elam| ELAM1| ELAM-1| endothelial adhesion molecule 1| endothelial leukocyte adhesion molecule 1| ESEL| E-selectin| LECAM2| leukocyte endothelial cell adhesion molecule 2| leukocyte-endothelial cell adhesion molecule 2| M959_12553| MDA_GLEAN10013466| N300_11960| N302_00504| N303_07923| N307_04714| N308_02225| N322_02130| N327_03004| N328_00694| N329_05554| N336_11872| N339_12518| PANDA_007105| P-selectin| selectin E (endothelial adhesion molecule 1)| selectin, endothelial cell| TREES_T100017097| uncharacterized protein LOC558139| UY3_08356| Y956_03437| sele

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