Summary of SELE
This gene encodes a protein that plays an important role during inflammation. It is associated with high cholesterol (R).
The Function of SELE
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.
Protein names
Recommended name:
E-selectinShort name:
ELAM-1Alternative name(s):
CD62 antigen-like family member EEndothelial leukocyte adhesion molecule 1
Leukocyte-endothelial cell adhesion molecule 2
LECAM2
CD antigen CD62E
- RS1805193 (SELE) ??
- RS5355 (SELE) ??
- RS5361 (SELE) ??
- RS5368 (SELE) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
SELE Interacts with These Diseases
| Disease | Score |
Substances That Increase SELE
| Substances | Interaction | Organism | Category |
Substances That Decrease SELE
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Essential hypertension
From NCBI Gene: The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008] From UniProt: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Transmembrane Signaling Receptor Activity
- Sialic Acid Binding
- Phospholipase Binding
- Oligosaccharide Binding
Biological Processes:
- Positive Regulation Of Receptor Internalization
- Leukocyte Migration Involved In Inflammatory Response
- Inflammatory Response
- Heterophilic Cell-Cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
- Leukocyte Cell-Cell Adhesion
- Activation Of Phospholipase C Activity
- Calcium-Mediated Signaling
- Actin Filament-Based Process
- Response To Lipopolysaccharide
- Response To Tumor Necrosis Factor
- Regulation Of Inflammatory Response
- Leukocyte Migration
- Leukocyte Tethering Or Rolling
- Response To Interleukin-1