The Function of SCUBE1
Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.
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Protein names
Recommended name:
Signal peptide, CUB and EGF-like domain-containing protein 1- RS139014 (SCUBE1) ??
- RS5751452 (SCUBE1) ??
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Top Gene-Substance Interactions
Substances That Increase SCUBE1
| Substances | Interaction | Organism | Category |
Substances That Decrease SCUBE1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in endothelial cells. Highly expressed in platelets. Stored in platelet alpha granules, and transferred to the cell surface upon activation and aggregation. A smaller form, probably produced by limited proteolysis, after being released from the storage granules, is associated with thrombus and localized with the subendothelial matrices in atherosclerotic plaques.
Induction:
Down-regulated by inflammatory cytokines.
Molecular Function:
Biological Processes:
- Adult Heart Development
- Blood Coagulation
- Endothelial Cell Differentiation
- Inflammatory Response
- Post-Embryonic Development
- Protein Homooligomerization