The Function of SCN7A
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
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Top Gene-Substance Interactions
Substances That Increase SCN7A
| Substances | Interaction | Organism | Category |
Substances That Decrease SCN7A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Heart and uterus.
Molecular Function:
Biological Processes:
- Membrane Depolarization During Action Potential
- Muscle Contraction
- Neuronal Action Potential
- Sodium Ion Homeostasis
- Sodium Ion Transport