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  3. SCN7A

SCN7A (Sodium voltage-gated channel alpha subunit 7)

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The Function of SCN7A

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.

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Top Gene-Substance Interactions

Substances That Increase SCN7A

Substances Interaction Organism Category

Substances That Decrease SCN7A

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1
  • RORalpha1
  • Egr-1
  • RORalpha2
  • FOXF2
  • Egr-2
  • E4BP4

Tissue specificity:

Heart and uterus.

Molecular Function:

  • Voltage-Gated Sodium Channel Activity

Biological Processes:

  • Membrane Depolarization During Action Potential
  • Muscle Contraction
  • Neuronal Action Potential
  • Sodium Ion Homeostasis
  • Sodium Ion Transport

Drug Bank:

  • Valproic Acid
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

Sodium channel protein type 2 subunit alpha| CB1_000497004| D623_10034907| H920_16157| I79_013050| M91_17710| MDA_GLEAN10024229| N311_04695| N320_00212| NaG| Na-G| Nav2| Nav2.1| Nav2.2| Nav2.3| Nax| PAL_GLEAN10025923| PANDA_013070| putative voltage-gated sodium channel subunit alpha Nax| Scn6a| sodium channel protein cardiac and skeletal muscle subunit alpha| Sodium channel protein type 7 subunit alpha| Sodium channel protein type 9 subunit alpha| sodium channel protein type VII subunit alpha| sodium channel, voltage-gated, type 6, alpha polypeptide| sodium channel voltage-gated type VI alpha polypeptide| sodium channel, voltage-gated, type VI, alpha polypeptide| sodium channel voltage-gated type VII alpha| sodium channel, voltage-gated, type VII, alpha| sodium channel, voltage-gated, type VII, alpha subunit| TREES_T100003172| voltage-dependent sodium channel alpha subunit| scn7a

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