The Function of SCN3A
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
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Protein names
Recommended name:
Sodium channel protein type 3 subunit alphaAlternative name(s):
Sodium channel protein brain III subunit alphaSodium channel protein type III subunit alpha
Voltage-gated sodium channel subtype III
Voltage-gated sodium channel subunit alpha Nav1.3
- RS776488 (SCN3A) ??
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Top Gene-Substance Interactions
SCN3A Interacts with These Diseases
| Disease | Score |
Substances That Increase SCN3A
| Substances | Interaction | Organism | Category |
Substances That Decrease SCN3A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
Biological Processes:
- Sodium Ion Transport
- Nervous System Development
- Response To Wounding
- Neuronal Action Potential
- Sensory Perception Of Pain
- Response To Pyrethroid
- Cellular Response To Antibiotic
- Membrane Depolarization During Action Potential