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  3. SCN3A

SCN3A (Sodium voltage-gated channel alpha subunit 3)

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The Function of SCN3A

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.

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Protein names

Recommended name:

Sodium channel protein type 3 subunit alpha

Alternative name(s):

Sodium channel protein brain III subunit alpha
Sodium channel protein type III subunit alpha
Voltage-gated sodium channel subtype III
Voltage-gated sodium channel subunit alpha Nav1.3

SCN3A SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS776488 (SCN3A) ??

Top Gene-Substance Interactions

SCN3A Interacts with These Diseases

Disease Score

Substances That Increase SCN3A

Substances Interaction Organism Category

Substances That Decrease SCN3A

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • C/EBPalpha
  • MEF-2A
  • NF-E2
  • NF-E2 p45
  • Bach2
  • TGIF

Molecular Function:

  • Voltage-Gated Sodium Channel Activity
  • Sodium Ion Binding

Biological Processes:

  • Membrane Depolarization During Action Potential
  • Neuronal Action Potential
  • Sodium Ion Transport
  • Cellular Response To Antibiotic
  • Nervous System Development
  • Response To Pyrethroid
  • Response To Wounding
  • Sensory Perception Of Pain

Drug Bank:

  • Valproic Acid
  • Zonisamide
  • Lacosamide
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Sodium channel protein type 2 subunit alpha| brain III voltage-gated sodium channel| CB1_000616007| H920_16148| I79_007864| MDA_GLEAN10024222| N303_07181| NAC3| na(v)1.3| nav1.3| Nav1.3 sodium channel protein| PAL_GLEAN10025914| SCIII| Scn2a| SCN9A| sodium channel protein brain III subunit alpha| sodium channel protein, brain III subunit alpha| sodium channel protein type 2 subunit alpha-like protein| sodium channel protein type 3 subunit alpha| sodium channel protein type 3 subunit alpha-like| Sodium channel protein type III alpha subunit isoform 7-like protein| sodium channel protein type III subunit alpha| sodium channel, voltage-gated, type 3, alpha subunit| sodium channel, voltage-gated, type III, alpha| sodium channel, voltage-gated, type III, alpha polypeptide| sodium channel, voltage gated, type III alpha subunit| sodium channel, voltage-gated, type III, alpha subunit| sodium channel, voltage-gated, type IX, alpha subunit| TREES_T100019814| voltage-dependent sodium channel SCN3A| voltage-gated sodium channel Nav1.3 variant a| voltage-gated sodium channel Nav1.3 variant b| voltage-gated sodium channel subtype III| voltage-gated sodium channel subunit alpha Nav1.3| scn3a

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