The Function of SCG5
Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
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Protein names
Recommended name:
Neuroendocrine protein 7B2Alternative name(s):
Pituitary polypeptideSecretogranin V
Secretogranin-5
Secretory granule endocrine protein I
- RS10114408 (SCG5) ??
- RS4779584 (SCG5) ??
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Top Gene-Substance Interactions
Substances That Increase SCG5
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Substances That Decrease SCG5
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Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Molecular Function:
Biological Processes:
- Intracellular Protein Transport
- Neuropeptide Signaling Pathway
- Peptide Hormone Processing
- Regulation Of Hormone Secretion