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  3. SCG5

SCG5 (Secretogranin V)

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The Function of SCG5

Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.

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Protein names

Recommended name:

Neuroendocrine protein 7B2

Alternative name(s):

Pituitary polypeptide
Secretogranin V
Secretogranin-5
Secretory granule endocrine protein I

SCG5 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10114408 (SCG5) ??
  2. RS4779584 (SCG5) ??

Top Gene-Substance Interactions

Substances That Increase SCG5

Substances Interaction Organism Category

Substances That Decrease SCG5

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun

Molecular Function:

  • Enzyme Inhibitor Activity
  • Gtp Binding
  • Unfolded Protein Binding

Biological Processes:

  • Intracellular Protein Transport
  • Neuropeptide Signaling Pathway
  • Peptide Hormone Processing
  • Regulation Of Hormone Secretion
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 7B2| A306_08047| AS27_01249| AS28_07393| CB1_002341007| D623_10022182| EGK_17306| EH28_15812| GekBS052P| GW7_17377| H920_05518| I79_021619| M959_13289| N301_02068| N303_03460| N305_01159| N306_10804| N307_10046| N308_15761| N309_07730| N310_08652| N311_12486| N320_02733| N321_13813| N322_12556| N324_10641| N326_03423| N327_07287| N328_01171| N330_12901| N331_12150| N332_00906| N333_09035| N334_14350| N335_09804| N336_03314| N340_04676| Neuroendocrine protein 7B2| neuroendocrine protein 7B2-like protein| neuronal endocrine protein| P7B2| PAL_GLEAN10023649| PANDA_006212| pituitary polypeptide| prohormone convertase chaperone| secretogranin-5| secretogranin V (7B2 protein)| secretory granule endocrine protein I| secretory granule neuroendocrine protein 1| secretory granule, neuroendocrine protein 1| secretory granule neuroendocrine protein 1, 7B2 protein| secretory granule, neuroendocrine protein 1 (7B2 protein)| Secretory granule neuroendocrine, protein 1 (7B2 protein)| sgne1| Sgne-1| SgV| TREES_T100012887| UY3_16161| Y956_02703| Z169_03934| scg5

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