Summary of SCARB1
The SCARB1 gene encodes scavenger receptor class B member 1 [R].
This protein is a receptor for high density lipoprotein (HDL). It helps cholesterol bind to HDL, making HDL cholesterol, which is sometimes known as “good” cholesterol [R, R].
Variants in the SCARB1 gene have been linked to [R, R, R]:
- Atherosclerosis
- Cholesterol imbalance
- Obesity
Protein names
Recommended name:
Scavenger receptor class B member 1Short name:
SRB1Alternative name(s):
CD36 and LIMPII analogous 1CLA-1
CD36 antigen-like 1
Collagen type I receptor, thrombospondin receptor-like 1
SR-BI
CD antigen CD36
- RS10846744 (SCARB1) ??
- RS11057830 (SCARB1) ??
- RS11057841 (SCARB1) ??
- RS1672879 (SCARB1) ??
- RS4238001 (SCARB1) ??
- RS4765623 (SCARB1) ??
- RS5888 (SCARB1) ??
- RS838880 (SCARB1) ??
- RS838886 (SCARB1) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
SCARB1 Interacts with These Diseases
| Disease | Score |
Substances That Increase SCARB1
| Substances | Interaction | Organism | Category |
Substances That Decrease SCARB1
| Substances | Interaction | Organism | Category |
Advanced Summary
The protein encoded by this gene is a plasma membrane receptor for high-density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for the hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011] From UniProt: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine, and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for the hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester. (Microbial infection) Acts as a receptor for the hepatitis C virus in hepatocytes.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed.
Gene Pathways:
Molecular Function:
- Lipopolysaccharide Binding
- Virus Receptor Activity
- Phosphatidylserine Binding
- Lipopolysaccharide Receptor Activity
- Transporter Activity
- 1-Phosphatidylinositol Binding
- High-Density Lipoprotein Particle Binding
- Low-Density Lipoprotein Particle Binding
- Apolipoprotein Binding
- Apolipoprotein A-I Binding
- High-Density Lipoprotein Particle Receptor Activity
Biological Processes:
- Endothelial Cell Proliferation
- Androgen Biosynthetic Process
- Cholesterol Catabolic Process
- Receptor-Mediated Endocytosis
- Positive Regulation Of Endothelial Cell Migration
- Positive Regulation Of Triglyceride Biosynthetic Process
- Positive Regulation Of Cholesterol Storage
- Regulation Of Phosphatidylcholine Catabolic Process
- Phospholipid Transport
- Lipopolysaccharide Transport
- Detection Of Lipopolysaccharide
- Cholesterol Efflux
- High-Density Lipoprotein Particle Remodeling
- Low-Density Lipoprotein Particle Clearance
- High-Density Lipoprotein Particle Clearance
- Vitamin Transmembrane Transport
- Wound Healing
- Lipoprotein Metabolic Process
- Cholesterol Homeostasis
- Blood Vessel Endothelial Cell Migration
- Recognition Of Apoptotic Cell
- Reverse Cholesterol Transport
- Adhesion Of Symbiont To Host
- Regulation Of Phagocytosis
- Intestinal Absorption
- Positive Regulation Of Nitric-Oxide Synthase Activity
- Triglyceride Homeostasis
- Cholesterol Import
Drug Bank:
- Phosphatidylserine