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  3. S1PR2

S1PR2 (Sphingosine-1-phosphate receptor 2)

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Summary of S1PR2

This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation.

 Diseases associated with S1PR2 include Deafness.

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The Function of S1PR2

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

Protein names

Recommended name:

Sphingosine 1-phosphate receptor 2

Short name:

S1P2

Alternative name(s):

S1P receptor 2
Endothelial differentiation G-protein coupled receptor 5
Sphingosine 1-phosphate receptor Edg-5
S1P receptor Edg-5

S1PR2 SNPs

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  1. RS2116940 (S1PR2) ??

Top Gene-Substance Interactions

S1PR2 Interacts with These Diseases

Disease Score

Substances That Increase S1PR2

Substances Interaction Organism Category

Substances That Decrease S1PR2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • c-Jun
  • deltaCREB
  • GATA-1
  • c-Rel
  • Bach2
  • MIF-1

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction

Molecular Function:

  • G-Protein Coupled Receptor Activity
  • G-Protein Coupled Receptor Binding
  • Integrin Binding
  • Lipid Binding
  • Sphingosine-1-Phosphate Receptor Activity

Biological Processes:

  • Actin Cytoskeleton Reorganization
  • Activation Of Mapk Activity
  • Filopodium Assembly
  • G-Protein Coupled Receptor Signaling Pathway
  • Negative Regulation Of Excitatory Postsynaptic Potential
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Establishment Of Endothelial Barrier
  • Positive Regulation Of Peptidyl-Threonine Phosphorylation
  • Sphingosine-1-Phosphate Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| G-protein coupled receptor 13| AGR16| CB1_000418015| CTD-2369P2.2| DFNB68| EDG5| EDG-5| EGK_07434| EH28_05211| endothelial differentiation G-protein coupled receptor 5| endothelial differentiation, sphingolipid G-protein-coupled receptor, 5| Gpcr13| GPCR18| G-protein coupled receptor H218| G-protein-coupled sphingosine-1-phosphate receptor EDG5| H218| H920_09688| LPB2| lysophospholipid G protein-coupled receptor S1P2| lysophospholipid receptor B2| MDA_GLEAN10009310| mil| miles apart| PAL_GLEAN10002438| PANDA_010326| S1P2| S1P receptor 2| S1P receptor Edg-5| S1P receptor EDG5| snGPCR18| sphingosine 1-phosphate receptor 2| sphingosine 1-phosphate receptor Edg-5| sphingosine-1-phosphate receptor S1P(2)| TREES_T100002064| UY3_17944| xts1p2| Y1Q_009820| s1pr2

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