Summary of S1PR2
This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation.
Diseases associated with S1PR2 include Deafness.
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The Function of S1PR2
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
Protein names
Recommended name:
Sphingosine 1-phosphate receptor 2Short name:
S1P2Alternative name(s):
S1P receptor 2Endothelial differentiation G-protein coupled receptor 5
Sphingosine 1-phosphate receptor Edg-5
S1P receptor Edg-5
- RS2116940 (S1PR2) ??
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Top Gene-Substance Interactions
S1PR2 Interacts with These Diseases
| Disease | Score |
Substances That Increase S1PR2
| Substances | Interaction | Organism | Category |
Substances That Decrease S1PR2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- G-Protein Coupled Receptor Activity
- G-Protein Coupled Receptor Binding
- Integrin Binding
- Lipid Binding
- Sphingosine-1-Phosphate Receptor Activity
Biological Processes:
- Actin Cytoskeleton Reorganization
- Activation Of Mapk Activity
- Filopodium Assembly
- G-Protein Coupled Receptor Signaling Pathway
- Negative Regulation Of Excitatory Postsynaptic Potential
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Establishment Of Endothelial Barrier
- Positive Regulation Of Peptidyl-Threonine Phosphorylation
- Sphingosine-1-Phosphate Signaling Pathway