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  3. S100A6

S100A6 (S100 calcium binding protein A6)

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The Function of S100A6

May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.

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Protein names

Recommended name:

Protein S100-A6

Short name:

PRA

Alternative name(s):

Calcyclin
Growth factor-inducible protein 2A9
MLN 4
Prolactin receptor-associated protein
S100 calcium-binding protein A6

S100A6 SNPs

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  1. RS4845552 (S100A6) ??

Top Gene-Substance Interactions

S100A6 Interacts with These Diseases

Disease Score

Substances That Increase S100A6

Substances Interaction Organism Category

Substances That Decrease S100A6

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • AP-1
  • AhR
  • c-Jun
  • NF-kappaB1
  • C/EBPalpha
  • c-Myc
  • Sp1
  • c-Fos

Induction:

Preferentially expressed when quiescent fibroblasts are stimulated to proliferate. It is inducible by growth factors and overexpressed in acute myeloid leukemias.

Molecular Function:

  • Calcium-Dependent Protein Binding
  • Calcium Ion Binding
  • Ion Transmembrane Transporter Activity
  • Protein Homodimerization Activity
  • S100 Protein Binding
  • Tropomyosin Binding
  • Zinc Ion Binding

Biological Processes:

  • Axonogenesis
  • Positive Regulation Of Fibroblast Proliferation
  • Signal Transduction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 2A9| 5B10| CABP| CACY| calcium binding protein A6 (calcyclin)| calcyclin| CB1_000306045| EGK_01326| growth factor-inducible protein 2A9| lung 10 kDa protein| M91_03024| MLN 4| PANDA_011567| PRA| prolactin receptor-associated protein| Protein S100-A6| S100A5| S100 calcium binding protein A5| S100 calcium-binding protein A6| S100 calcium binding protein A6 (calcyclin)| S100 calcium-binding protein A6 (calcyclin)| TREES_T100021951| UY3_14669| s100a6

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