The Function of S100A6
May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.
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Protein names
Recommended name:
Protein S100-A6Short name:
PRAAlternative name(s):
CalcyclinGrowth factor-inducible protein 2A9
MLN 4
Prolactin receptor-associated protein
S100 calcium-binding protein A6
- RS4845552 (S100A6) ??
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Top Gene-Substance Interactions
S100A6 Interacts with These Diseases
| Disease | Score |
Substances That Increase S100A6
| Substances | Interaction | Organism | Category |
Substances That Decrease S100A6
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Induction:
Preferentially expressed when quiescent fibroblasts are stimulated to proliferate. It is inducible by growth factors and overexpressed in acute myeloid leukemias.
Molecular Function:
- Calcium-Dependent Protein Binding
- Calcium Ion Binding
- Ion Transmembrane Transporter Activity
- Protein Homodimerization Activity
- S100 Protein Binding
- Tropomyosin Binding
- Zinc Ion Binding