Summary of RXRA
The gene codes for a protein, retinoid X receptor alpha. The protein is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators [R].
The Function of RXRA
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.
Protein names
Recommended name:
Retinoic acid receptor RXR-alphaAlternative name(s):
Nuclear receptor subfamily 2 group B member 1Retinoid X receptor alpha
- RS1045570 (RXRA) ??
- RS11102986 (RXRA) ??
- RS1536475 (RXRA) ??
- RS1805352 (RXRA) ??
- RS3118536 (RXRA) ??
- RS34312136 (RXRA) ??
- RS35079168 (RXRA) ??
- RS4501664 (RXRA) ??
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Top Gene-Substance Interactions
RXRA Interacts with These Diseases
| Disease | Score |
Substances That Increase RXRA
| Substances | Interaction | Organism | Category |
Substances That Decrease RXRA
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in liver, also found in lung, kidney and heart.
Gene Pathways:
Molecular Function:
- Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
- Dna Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Steroid Hormone Receptor Activity
- Retinoic Acid Receptor Activity
- Transcription Coactivator Activity
- Rna Polymerase Ii Transcription Factor Activity, Ligand-Activated Sequence-Specific Dna Binding
- 9-Cis Retinoic Acid Receptor Activity
- Zinc Ion Binding
- Enzyme Binding
- Chromatin Dna Binding
- Vitamin D Receptor Binding
- Sequence-Specific Dna Binding
- Retinoic Acid-Responsive Element Binding
- Protein Heterodimerization Activity
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- In Utero Embryonic Development
- Liver Development
- Maternal Placenta Development
- Transcription Initiation From Rna Polymerase Ii Promoter
- Vitamin Metabolic Process
- Inflammatory Response
- Midgut Development
- Embryo Implantation
- Aging
- Cholesterol Metabolic Process
- Negative Regulation Of Cell Proliferation
- Response To Selenium Ion
- Bile Acid And Bile Salt Transport
- Modulation By Virus Of Host Morphology Or Physiology
- Axon Regeneration
- Regulation Of Myelination
- Response To Retinoic Acid
- Cellular Response To Insulin Stimulus
- Response To Vitamin A
- Response To Vitamin D
- Peroxisome Proliferator Activated Receptor Signaling Pathway
- Camera-Type Eye Development
- Positive Regulation Of Apoptotic Process
- Cellular Lipid Metabolic Process
- Response To Ethanol
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Translational Initiation By Iron
- Retinoic Acid Receptor Signaling Pathway
- Protein Homotetramerization
- Response To Glucocorticoid
- Ventricular Cardiac Muscle Tissue Morphogenesis
- Ventricular Cardiac Muscle Cell Differentiation
- Cardiac Muscle Cell Proliferation
- Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development
- Regulation Of Branching Involved In Prostate Gland Morphogenesis
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter Involved In Cellular Response To Chemical Stimulus