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  3. RTN4

RTN4 (Reticulon 4)

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The Function of RTN4

Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. Induces the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:25612671, PubMed:24262037). Regulates membrane morphogenesis in the ER by promoting tubular ER production. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412).

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Protein names

Recommended name:

Reticulon-4

Short name:

NSP

Alternative name(s):

Foocen
Neurite outgrowth inhibitor
Nogo protein
Neuroendocrine-specific protein
Neuroendocrine-specific protein C homolog
RTN-x
Reticulon-5

Top Gene-Substance Interactions

RTN4 Interacts with These Diseases

Disease Score

Substances That Increase RTN4

Substances Interaction Organism Category

Substances That Decrease RTN4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • C/EBPalpha
  • p300

Tissue specificity:

Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis-specific.

Gene Pathways:

  • Signal Transduction

Molecular Function:

  • Cadherin Binding Involved In Cell-Cell Adhesion
  • Poly(A) Rna Binding

Biological Processes:

  • Apoptotic Process
  • Axonal Fasciculation
  • Cardiac Epithelial To Mesenchymal Transition
  • Cerebral Cortex Radial Glia Guided Migration
  • Endoplasmic Reticulum Tubular Network Assembly
  • Endoplasmic Reticulum Tubular Network Organization
  • Negative Regulation Of Axon Extension
  • Negative Regulation Of Axonogenesis
  • Negative Regulation Of Cell Growth
  • Nuclear Pore Complex Assembly
  • Regulation Of Apoptotic Process
  • Regulation Of Branching Morphogenesis Of A Nerve
  • Regulation Of Cell Migration
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| r| glucosidase 2 subunit beta| NSP| AS27_04180| AS28_01708| asy| CB1_000157016| D623_10034334| foocen| GekBS142P| glut4 vesicle 20 kDa protein| GLUT4 vesicle 20kDa protein| H920_20165| Human NogoA| I79_010923| My043 protein| N301_10957| N302_14394| N303_00741| N306_03659| N307_02228| N308_02499| N309_10740| N324_00431| N326_01490| N327_04334| N328_11767| N332_11712| N333_03128| N334_04342| N335_08723| N336_00734| N340_12763| N341_03882| Nbla00271| Nbla10545| neurite growth inhibitor 220| neurite outgrowth inhibitor| neuroendocrine-specific protein C homolog| NgA| NI-220/250| NI220/250| NI-250| Nogo| Nogo-A| Nogo-B| Nogo-C| NOGOC| nogo protein| NSP-CL| PAL_GLEAN10021247| PANDA_001932| rat N| rat NogoA| Reticulon-4| Reticulon 4 isoform 3-like protein| Reticulon-4-like protein| reticulon 5| RTN4-A| rtn4-b| RTN4-B1| RTN4-B2| RTN4-C| RTN4-Cw| RTN4-N| RTN-X| TREES_T100001972| UY3_16842| Vp20| Y1Q_002054| Z169_04037| rtn4

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