The Function of RTN4
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. Induces the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:25612671, PubMed:24262037). Regulates membrane morphogenesis in the ER by promoting tubular ER production. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412).
Protein names
Recommended name:
Reticulon-4Short name:
NSPAlternative name(s):
FoocenNeurite outgrowth inhibitor
Nogo protein
Neuroendocrine-specific protein
Neuroendocrine-specific protein C homolog
RTN-x
Reticulon-5
Top Gene-Substance Interactions
RTN4 Interacts with These Diseases
| Disease | Score |
Substances That Increase RTN4
| Substances | Interaction | Organism | Category |
Substances That Decrease RTN4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis-specific.
Gene Pathways:
Molecular Function:
Biological Processes:
- Apoptotic Process
- Axonal Fasciculation
- Cerebral Cortex Radial Glia Guided Migration
- Negative Regulation Of Cell Growth
- Regulation Of Cell Migration
- Negative Regulation Of Axon Extension
- Regulation Of Apoptotic Process
- Negative Regulation Of Axonogenesis
- Nuclear Pore Complex Assembly
- Cardiac Epithelial To Mesenchymal Transition
- Endoplasmic Reticulum Tubular Network Organization
- Endoplasmic Reticulum Tubular Network Assembly
- Regulation Of Branching Morphogenesis Of A Nerve