The Function of RRM2
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
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Protein names
Recommended name:
Ribonucleoside-diphosphate reductase subunit M2Alternative name(s):
Ribonucleotide reductase small chainRibonucleotide reductase small subunit
- RS1130609 (RRM2) ??
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Top Gene-Substance Interactions
RRM2 Interacts with These Diseases
| Disease | Score |
Substances That Increase RRM2
| Substances | Interaction | Organism | Category |
Substances That Decrease RRM2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Cofactor:
Binds 2 iron ions per subunit.
Molecular Function:
Biological Processes:
- Deoxyribonucleotide Biosynthetic Process
- Dna Replication
- G1/S Transition Of Mitotic Cell Cycle
- Nucleobase-Containing Small Molecule Interconversion
- Protein Heterotetramerization
- Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
- Deoxyribonucleoside Diphosphate Metabolic Process