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  3. RRM2

RRM2 (Ribonucleotide reductase regulatory subunit M2)

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The Function of RRM2

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.

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Protein names

Recommended name:

Ribonucleoside-diphosphate reductase subunit M2

Alternative name(s):

Ribonucleotide reductase small chain
Ribonucleotide reductase small subunit

RRM2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1130609 (RRM2) ??

Top Gene-Substance Interactions

RRM2 Interacts with These Diseases

Disease Score

Substances That Increase RRM2

Substances Interaction Organism Category

Substances That Decrease RRM2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • CREB
  • AP-1
  • c-Jun
  • deltaCREB
  • NF-kappaB1
  • Sp1
  • E2F-1
  • HSF2

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Glutathione metabolism
  • p53 signaling pathway
  • Purine metabolism
  • Pyrimidine metabolism

Cofactor:

Binds 2 iron ions per subunit.

Molecular Function:

  • Metal Ion Binding
  • Ribonucleoside-Diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor

Biological Processes:

  • Deoxyribonucleotide Biosynthetic Process
  • Dna Replication
  • G1/S Transition Of Mitotic Cell Cycle
  • Nucleobase-Containing Small Molecule Interconversion
  • Protein Heterotetramerization
  • Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
  • Deoxyribonucleoside Diphosphate Metabolic Process

Drug Bank:

  • Gallium Nitrate
  • Cladribine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

AS28_03589| CB1_001616078| chunp6884| D623_10020829| etID309896.20| GW7_13019| H920_07398| M91_14570| M959_14784| MDA_GLEAN10012555| N300_15337| N301_06692| N302_01873| N303_09054| N305_01617| N306_06096| N307_06764| N308_15457| N326_11648| N332_06409| N336_05896| PAL_GLEAN10020126| r2| reductase M2 polypeptide variant 1| reductase M2 polypeptide variant 2| reductase M2 polypeptide variant 3a| reductase M2 polypeptide variant 3b| reductase M2 polypeptide variant 3c| reductase M2 polypeptide variant 3d| ribonucleoside-diphosphate reductase M2 chain| ribonucleoside-diphosphate reductase subunit M2| ribonucleoside-diphosphate reductase subunit M2-like protein| Ribonucleotide reductase 2| ribonucleotide reductase M2| ribonucleotide reductase M2 B (TP53 inducible)| ribonucleotide reductase M2 polypeptide| ribonucleotide reductase protein r2 class I| ribonucleotide reductase small chain| ribonucleotide reductase small subunit| RIR2| RR2| RR2M| RRM2B| TREES_T100010423| UY3_00721| Y1Q_002001| Y956_15347| rrm2

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