The Function of RRAGB
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates to the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway.
Protein names
Recommended name:
Ras-related GTP-binding protein BAlternative name(s):
Rag BRagB
Top Gene-Substance Interactions
Substances That Increase RRAGB
| Substances | Interaction | Organism | Category |
Substances That Decrease RRAGB
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Enzyme Regulation:
The activation of GTP-binding proteins is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). The GATOR1 complex functions as a GAP and stimulates RRAGB GTPase activity to turn it into its inactive GDP-bound form.
Molecular Function:
Biological Processes:
- Cell Cycle Arrest
- Cellular Protein Localization
- Cellular Response To Amino Acid Starvation
- Cellular Response To Amino Acid Stimulus
- Macroautophagy
- Positive Regulation Of Tor Signaling
- Regulation Of Autophagy
- Regulation Of Tor Signaling